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Article, Chapter, or Book Title:  Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin
Author(s):  Idowu OR, Peggins JO, Cullison R, and von Bredow J
Year:  2010
Month:  Oct
Journal Abbrev, Book Title, or Conference:  Res Vet Sci
Journal Full Name:  Research in Veterinary Science
Issue:  2
Volume:  89
Start Page:  230
End Page:  235
Key Words:  pharmacokinetics, enrofloxacin, ciprofloxacin, lactating cows, steers
Abstract:  The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. Within either bovine class, plasma elimination half-life of enrofloxacin and ciprofloxacin are comparable, while plasma protein binding was higher for enrofloxacin than for ciprofloxacin. ciprofloxacin was more concentrated in milk than enrofloxacin.