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U.S. Department of Health and Human Services

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Article, Chapter, or Book Title:  Comparative pharmacokinetics of enrofloxacin and ciprofloxacin in lactating dairy cows and beef steers following intravenous administration of enrofloxacin
 
Author(s):  Idowu OR, Peggins JO, Cullison R, and von Bredow J
 
Year:  2010
 
Month:  Oct
 
Journal Abbrev, Book Title, or Conference:  Res Vet Sci
 
Journal Full Name:  Research in Veterinary Science
 
Issue:  2
 
Volume:  89
 
Start Page:  230
 
End Page:  235
 
Key Words:  pharmacokinetics, enrofloxacin, ciprofloxacin, lactating cows, steers
 
Abstract:  The comparative pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin were investigated in lactating cows and beef steers. The plasma elimination half-life of either enrofloxacin or ciprofloxacin was shorter in cows than in steers. Within either bovine class, plasma elimination half-life of enrofloxacin and ciprofloxacin are comparable, while plasma protein binding was higher for enrofloxacin than for ciprofloxacin. ciprofloxacin was more concentrated in milk than enrofloxacin.
 
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