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U.S. Department of Health and Human Services

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Article, Chapter, or Book Title:  Determination of an Oral Aflatoxin Dose that Acutely Impairs Hepatic Function in Domestic Pigeons (Columba livia)
 
Author(s):  Haley TL, Grizzle J, Rotstein DS, et al.
 
Year:  2010
 
Journal Abbrev, Book Title, or Conference:  J Avian Med Surg
 
Journal Full Name:  Journal of Avian Medicine and Surgery
 
Volume:  24
 
Start Page:  210
 
End Page:  221
 
Key Words:  aflatoxin B-1, hepatoxin, birds, model of hepatotoxicosis, Carneaux pigeons, mycotoxin, histopathological evaluation, liver, scintigraphy, bile acid testing
 
Abstract:  Aflatoxin B-1 is a common hepatotoxin in birds. The study goal was to establish an acute model for hepatotoxicosis and decreased hepatic function in white Carneaux pigeons receiving an oral bolus of mycotoxoin, Aflatoxin B-1. Evaluation included clinical pathology, scintigraphy, and histopathological evaluation of the liver. Histological evaluation and liver enzyme activity indicated hepatocellular damage, but scintigraphy and bile acid testing did not demonstrate decreased hepatic function.
 
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