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U.S. Department of Health and Human Services

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Article, Chapter, or Book Title:  Bioaccumulation of Melamine in Catfish Muscle Following Continuous, Low-Dose, Oral Administration
Author(s):  Andersen WC, Turnipseed SB, Karbiwnyk CM, Evans E, Hasbrouck N, Mayer TD, Gieseker CM, Nochetto C, Stine C, and Reimschuessel R.
Year:  2011
Journal Abbrev, Book Title, or Conference:  J Agric Food Chem
Journal Full Name:  Journal of Agricultural and Food Chemistry
Issue:  7
Volume:  59
Start Page:  3,111
End Page:  3,117
Key Words:  melamine, cyanuric acid, fish, dosing study
Abstract:  This study describes the accumulation of melamine in fish filets after feeding a low dose of 0.1 milligram (mg) melamine per kilogram (kg) of body weight, which is comparable to a dose of 2.5 mg/kg in feed. Maximum accumulation was reached after 28 days of dosing (0.33 mg/kg), with no significant additional accumulation occurring after 42 days of dosing (0.29 mg/kg). These levels are below the level of no concern of 2.5 mg/kg for foods established by the World Health Organization and risk assessors worldwide.