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U.S. Department of Health and Human Services

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Article, Chapter, or Book Title:  Dose-response assessment of nephrotoxicity from a seven-day combined-exposure to melamine and cyanuric acid in F344 rats
 
Author(s):  Jacob CC, Reimschuessel R, Von Tungeln LS, Olson GR, Warbritton AR, Hattan DG, Beland FA, and Gamboa da Costa G
 
Year:  2011
 
Journal Abbrev, Book Title, or Conference:  Toxicol Sci
 
Journal Full Name:  Toxicological Sciences
 
Issue:  2
 
Volume:  119
 
Start Page:  391
 
End Page:  397
 
Key Words:  melamine, cyanuric acid, melamine cyanurate, nephrotoxicity
 
Abstract:  This study examines the effect of combined melamine and cyanuric acid exposure in rats. Several different doses were given to rats and the effect on kidney function, blood values, and crystal formation in kidney tubules were examined. This study is designed to provide preliminary information for a longer-term rat exposure study which will be used to predict risk to humans following potential ingestion of these chemicals.
 
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