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U.S. Department of Health and Human Services

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Article, Chapter, or Book Title:  Comparative Genomics of 28 Salmonella enterica Isolates: Evidence for CRISPR-mediated Adaptive Sublineage Evolution
 
Author(s):  Fricke WF, Mammel MK, McDermott PF, Tartera C, White DG, Leclerc JE, Ravel J, Cebula TA
 
Year:  2011
 
Journal Abbrev, Book Title, or Conference:  J Bacteriol
 
Journal Full Name:  Journal of Bacteriology
 
Issue:  14
 
Volume:  193
 
Start Page:  3,556
 
End Page:  3,568
 
Key Words:  non-typhoidal Salmonella, genomes, comparative analysis, evolution, CRISPRs, signature DNA elements
 
Abstract:  In this study, we compared 17 newly sequenced and characterized non-typhoidal Salmonella strains to 11 previously sequenced genomes to carry out the most comprehensive comparative analysis in this species to date. Our findings suggest that the evolution of salmonellae is mostly mediated by two mechanisms: the loss of coding sequences with known metabolic functions, which leads to functional reduction, and by the acquisition of horizontally-transferred phage and plasmid DNA, which provide virulence and resistance functions and lead to increasing specialization. Signature DNA elements (called CRISPRs) could control short- and long-term evolution in Salmonella.
 
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