• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

The Paper Trail - Detail

  • Print
  • Share
  • E-mail
Article, Chapter, or Book Title:  Comparative Genomics of 28 Salmonella enterica Isolates: Evidence for CRISPR-mediated Adaptive Sublineage Evolution
Author(s):  Fricke WF, Mammel MK, McDermott PF, Tartera C, White DG, Leclerc JE, Ravel J, Cebula TA
Year:  2011
Journal Abbrev, Book Title, or Conference:  J Bacteriol
Journal Full Name:  Journal of Bacteriology
Issue:  14
Volume:  193
Start Page:  3,556
End Page:  3,568
Key Words:  non-typhoidal Salmonella, genomes, comparative analysis, evolution, CRISPRs, signature DNA elements
Abstract:  In this study, we compared 17 newly sequenced and characterized non-typhoidal Salmonella strains to 11 previously sequenced genomes to carry out the most comprehensive comparative analysis in this species to date. Our findings suggest that the evolution of salmonellae is mostly mediated by two mechanisms: the loss of coding sequences with known metabolic functions, which leads to functional reduction, and by the acquisition of horizontally-transferred phage and plasmid DNA, which provide virulence and resistance functions and lead to increasing specialization. Signature DNA elements (called CRISPRs) could control short- and long-term evolution in Salmonella.