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U.S. Department of Health and Human Services

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Article, Chapter, or Book Title:  Benzocaine-induced methemoglobinemia in an acute-exposure rat model
 
Author(s):  Von Tungeln LS, Zhou T, Woodling KA, Doerge DR, Greenlees KJ, and Beland FA
 
Year:  2011
 
Journal Abbrev, Book Title, or Conference:  Food and Chemical Toxicology
 
Journal Full Name:  Food and Chemical Toxicology
 
Issue:  10
 
Volume:  49
 
Start Page:  2,530
 
End Page:  2,539
 
Key Words:  rats, benzocaine, tricaine-methanesulfonate, methemoglobin
 
Abstract:  The study was conducted to determine if acute oral exposure to benzocaine could cause methemoglobinemia in rats. These data were used to estimate the potential impact of benzocaine residues in fish on the human consumer, and suggest that the consumption of fish treated with benzocaine hydrochloride will not cause methemoglobinemia in humans.
 
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