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NADA Number: 140-994

Proprietary Name Tolazine® Injection
Sponsor Akorn Animal Health, Inc.
Sponsor Address 1925 West Field Ct.
suite 300
Lake Forest, IL    60045
Ingredients Tolazoline Hydrochloride
Species (Class) EQUIDS (Horse, not for meat production)
Routes of Administration Intravenous
Dosage Form Liquid (solution)
Dispensing Status RX
Exclusivity No active ingredient of the drug has been previously approved.
Dosage Amount,
& Limitations

522.2474 Tolazine hydrochloride.

Specifications: Each milliliter of sterile aqueous solution contains tolazoline hydrochloride equivalent to 100 milligrams of base activity.

Conditions of use:


Amount: 100 milligrams per milliliter. Administer slowly by intravenous injection 4 milligrams per kilogram of body weight or 1.8 milligrams per pound.

Indications: For use in horses when it is desirable to reverse the effects of sedation and analgesia caused by xylazine.

Limitations: The safety of Tolazine has not been established in pregnant mares, lactating mares, horses intended for breeding, foals, or horses with metabolically unstable conditions. The safety of Tolazine has not been evaluated for reversing xylazine used as a preanesthetic to a general anesthetic. This drug is for use in horses only and not for use in food-producing animals. Users with cardiovascular disease (for example, hypertension or ischemic heart disease) should take special precautions to avoid accidental exposure to this product. Accidental spillage on skin should be washed off immediately with soap and water.