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U.S. Department of Health and Human Services

CFR - Code of Federal Regulations Title 21

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Help | More About 21CFR
[Code of Federal Regulations]
[Title 21, Volume 6]
[Revised as of April 1, 2013]
[CITE: 21CFR582.20]



TITLE 21--FOOD AND DRUGS
CHAPTER I--FOOD AND DRUG ADMINISTRATION
DEPARTMENT OF HEALTH AND HUMAN SERVICES
SUBCHAPTER E--ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS

PART 582 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE

Subpart A--General Provisions

Sec. 582.20 Essential oils, oleoresins (solvent-free), and natural extractives (including distillates).

Essential oils, oleoresins (solvent-free), and natural extractives (including distillates) that are generally recognized as safe for their intended use, within the meaning of section 409 of the act, are as follows:

Common nameBotanical name of plant source
AlfalfaMedicago sativaL.
AllspicePimenta officinalisLindl.
Almond, bitter (free from prussic acid)Prunus amygdalusBatsch,Prunus armeniacaL. orPrunus persica(L.) Batsch.
Ambrette (seed)Hibiscus moschatusMoench.
Angelica rootAngelica archangelicaL.
Angelica seed Do.
Angelica stem Do.
Angostura (cusparia bark)Galipea officinalisHancock.
AnisePimpinella anisumL.
AsafetidaFerula assa-foetidaL. and related spp. of Ferula.
Balm (lemon balm)Melissa officinalisL.
Balsam of PeruMyroxylon pereiraeKlotzsch.
BasilOcimum basilicumL.
Bay leavesLaurus nobilisL.
Bay (myrcia oil)Pimenta racemosa(Mill.) J. W. Moore.
Bergamot (bergamot orange)Citrus aurantiumL. subsp. bergamia Wright et Arn.
Bitter almond (free from prussic acid)Prunus amygdalusBatsch,Prunus armeniacaL., orPrunus persica(L.) Batsch.
Bois de roseAniba rosaeodoraDucke.
CacaoTheobroma cacaoL.
Camomile (chamomile) flowers, HungarianMatricaria chamomillaL.
Camomile (chamomile) flowers, Roman or EnglishAnthemis nobilisL.
CanangaCananga odorataHook. f. and Thoms.
CapsicumCapsicum frutescensL. andCapsicum annuumL.
CarawayCarum carviL.
Cardamom seed (cardamon)Elettaria cardamomumMaton.
Carob beanCeratonia siliquaL.
CarrotDaucus carotaL.
Cascarilla barkCroton eluteriaBenn.
Cassia bark, ChineseCinnamomum cassiaBlume.
Cassia bark, Padang or BataviaCinnamomum burmanniBlume.
Cassia bark, SaigonCinnamomum loureiriiNees.
Celery seedApium graveolensL.
Cherry, wild, barkPrunus serotinaEhrh.
ChervilAnthriscus cerefolium(L.) Hoffm.
ChicoryCichorium intybusL.
Cinnamon bark, CeylonCinnamomum zeylanicumNees.
Cinnamon bark, ChineseCinnamomum cassiaBlume.
Cinnamon bark, SaigonCinnamomum loureiriiNees.
Cinnamon leaf, CeylonCinnamomum zeylanicumNees.
Cinnamon leaf, ChineseCinnamomum cassiaBlume.
Cinnamon leaf, SaigonCinnamomum loureiriiNees.
CitronellaCymbopogon nardusRendle.
Citrus peelsCitrusspp.
Clary (clary sage)Salvia sclareaL.
Clove budEugenia caryophyllataThunb.
Clove leaf Do.
Clove stem Do.
CloverTrifoliumspp.
Coca (decocainized)Erythroxylum cocaLam. and other spp. of Erythroxylum.
CoffeeCoffeaspp.
Cola nutCola acuminataSchott and Endl., and other spp. of Cola.
CorianderCoriandrum sativumL.
Corn silkZea maysL.
Cumin (cummin)Cuminum cyminumL.
Curacao orange peel (orange, bitter peel)Citrus aurantiumL.
Cusparia barkGalipea officinalisHancock.
DandelionTaraxacum officinaleWeber andT. laevigatumDC.
Dandelion root Do.
DillAnethum graveolensL.
Dog grass (quackgrass, triticum)Agropyron repens(L.) Beauv.
Elder flowersSambucus canadensisL. and S. nigra L.
Estragole (esdragol, esdragon, tarragon)Artemisia dracunculusL.
Estragon (tarragon) Do.
Fennel, sweetFoeniculum vulgareMill.
FenugreekTrigonella foenum-graecumL.
Galanga (galangal)Alpinia officinarumHance.
GarlicAllium sativumL.
GeraniumPelargoniumspp.
Geranium, East IndianCymbopogon martiniStapf.
Geranium, rosePelargonium graveolensL'Her.
GingerZingiber officinaleRosc.
GlycyrrhizaGlycyrrhiza glabraL. and other spp. of Glycyrrhiza.
Glycyrrhizin, ammoniated Do.
GrapefruitCitrus paradisiMacf.
GuavaPsidiumspp.
Hickory barkCaryaspp.
Horehound (hoarhound)Marrubium vulgareL.
HopsHumulus lupulusL.
HorsemintMonarda punctataL.
HyssopHyssopus officinalisL.
ImmortelleHelichrysum augustifoliumDC.
JasmineJaminum officinaleL. and other spp. of Jasminum.
Juniper (berries)Juniperus communisL.
Kola nutCola acuminataSchott and Endl., and other spp. of Cola.
Laurel berriesLaurus nobilisL.
Laurel leavesLaurusspp.
LavenderLavandula officinalisChaix.
Lavender, spikeLavandula latifoliaVill.
LavandinHybrids betweenLavandula officinalisChaix andLavandula latifolinVill.
LemonCitrus limon(L.) Burm. f.
Lemon balm (see balm).
Lemon grassCymbopogon citratusDC. andCymbopogon flexuosusStapf.
Lemon peelCitrus limon(L.) Burm. f.
LicoriceGlycyrrhiza glabraL. and other spp. of Glycyrrhiza.
LimeCitrus aurantifoliaSwingle.
Linden flowersTiliaspp.
Locust beanCeratonia siliquaL.
LupulinHumulus lupulusL.
MaceMyristica fragransHoutt.
Malt (extract)Hordeum vulgareL., or other grains.
MandarinCitrus reticulataBlanco.
Marjoram, sweetMajorana hortensisMoench.
Mate 1Ilex paraguariensisSt. Hil.
Melissa (see balm).
MentholMenthaspp.
Menthyl acetate Do.
Molasses (extract)Saccharum officinarumL.
MustardBrassicaspp.
NaringinCitrus paradisiMacf.
Neroli, bigaradeCitrus aurantiumL.
NutmegMyristica fragransHoutt.
OnionAllium cepaL.
Orange, bitter, flowersCitrus aurantiumL.
Orange, bitter, peel Do.
Orange leafCitrus sinensis(L.) Osbeck.
Orange, sweet Do.
Orange, sweet, flowers Do.
Orange, sweet, peel Do.
OriganumOriganumspp.
PalmarosaCymbopogon martiniStapf.
PaprikaCapsicum annuumL.
ParsleyPetroselinum crispum(Mill.) Mansf.
Pepper, blackPiper nigrumL.
Pepper, whitePiper nigrumL.
PeppermintMentha piperitaL.
Peruvian balsamMyroxylon pereiraeKlotzsch.
PetitgrainCitrus aurantiumL.
Petitgrain lemonCitrus limon(L.) Burm. f.
Petitgrain mandarin or tangerineCitrus reticulataBlanco.
PimentaPimenta officinalisLindl.
Pimenta leafPrimenta officinalisLindl.
Pipsissewa leavesChimaphila umbellataNutt.
PomegranatePunica granatumL.
Prickly ash barkXanthoxylum(or Zanthoxylum)AmericanumMill. orXanthoxylum clava-herculisL.
Rose absoluteRosa albaL.,Rosa centifoliaL.,Rosa damascenaMill.,Rosa gallicaL., and vars. of these spp.
Rose (otto of roses, attar of roses) Do.
Rose buds Do.
Rose flowers Do.
Rose fruit (hips) Do.
Rose geraniumPelargonium graveolensL'Her.
Rose leavesRosaspp.
RosemaryRosmarinus officinalisL.
RueRuta graveolensL.
SaffronCrocus sativusL.
SageSalvia officinalisL.
Sage, GreekSalvia trilobaL.
Sage, SpanishSalvia lavandulaefoliaVahl.
St. John's breadCeratonia siliquaL.
Savory, summerSatureia hortensisL.
Savory, winterSatureia montanaL.
Schinus molleSchinus molleL.
Sloe berries (blackthorn berries)Prunus spinosaL.
SpearmintMentha spicataL.
Spike lavenderLavandula latifoliaVill.
TamarindTamarindus indicaL.
TangerineCitrus reticulataBlanco.
Tannic acidNutgalls ofQuercus infectoriaOliver and related spp. of Quercus. Also in many other plants.
TarragonArtemisia dracunculusL.
TeaThea sinensisL.
ThymeThymus vulgarisL. andThymus zygisvar. gracilis Boiss.
Thyme, white Do.
Thyme, wild or creepingThymus serpyllumL.
Triticum (see dog grass).
TuberosePolianthes tuberosaL.
TurmericCurcuma longaL.
VanillaVanilla planifoliaAndr. orVanilla tahitensisJ. W. Moore.
Violet flowersViola odorataL.
Violet leaves Do.
Violet leaves absolute Do.
Wild cherry barkPrunus serotinaEhrh.
Ylang-ylangCananga odorataHook. f. and Thoms.
Zedoary barkCurcuma zedoariaRosc.
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