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U.S. Department of Health and Human Services

Inventory of Effective Food Contact Substance (FCS) Notifications

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FCN No. 111

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Food Contact Substance:  2-Methyl-4-isothiazolin-3-one (CAS Reg. No. 2682-20-4) as a 20 percent solution.
Notifier:  Thor GmbH
Manufacturer:  Thor GmbH
Intended Use:  As an antimicrobial agent in adhesives and in components of adhesives for food-contact articles. As an antimicrobial agent in coating formulations and in additives used in the manufacture of paper and paperboard intended for use in contact with all food types.
Effective Date:  02/20/2001
Limitations/Specifications:  2-Methyl-4-isothiazolin-3-one is not to exceed 150 mg/kg in the coating formulations and additives; except for use as an antimicrobial agent for polymer latex emulsions in paper coatings, 2-methyl-4-isothiazolin-3-one shall not exceed 250 mg/kg. The use of 2-methyl-4-isothiazolin-3-one in adhesives shall be in accordance with 21 CFR 175.105.
Environmental Impact Decisions:  Environmental Decisions Site