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U.S. Department of Health and Human Services

Database of Select Committee on GRAS Substances (SCOGS) Reviews

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Gum Ghatti

 
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Report No.:  12
 
Type of Conclusion:  2
 
ID Code:  9000-28-6
 
Year:  1973
 
CFR Section:  184.1333
 
SCOGS Opinion:  There is no evidence that consumption of gum ghatti by man has has adverse effects when used at present levels. However, this presumption of lack of hazard is based primarily on the absence of evidence of human toxicity, rather than on substantive evidence supporting this conclusion. In view of the sparseness of toxicity data, the Select Committee attaches greater possible significance to the preliminary evidence indicating the maternal toxicity of gum ghatti at very high oral doses to pregnant rats and rabbits than it might otherwise accord these few data. It may be advisable, in due course, to conduct feeding studies in several animal species, including pregnant animals, at dosage levels that approximate and exceed the current estimated maximum daily human intake. The Select Committee has weighed the foregoing and concludes that: There is no evidence in available information on gum ghatti that demonstrates a hazard to the public when it is used at levels that are now current and in the manner now practiced.
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