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U.S. Department of Health and Human Services

Database of Select Committee on GRAS Substances (SCOGS) Reviews

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Sodium thiosulfate

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Report No.:  52
Type of Conclusion:  1
ID Code:  10102-17-7
Year:  1975
CFR Section:  184.1807
SCOGS Opinion:  Thiosulfate is a normal constituent fo human body fluids, and is a metabolite of dietary constituents. Experimental animal studies show that sodium thiosulfate is well tolerated. All investigations in which it has been administered to normal and diseased persons, clearly show that very large therapeutic doses cause no adverse effects. The reported use of sodium thiosulfate as a stabilizer of potassium iodide salt, as a sequestrant in alcoholic beverages, and as a substance that may migrate to foods from packaging materials, results in human exposure far below that needed to produce untoward biological effects. The Select Committee has weighed the foregoing and concludes that: There is no evidence in the available information on sodium thiosulfate that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when it is used at levels that are now current or that might reasonably be expected in the future.