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U.S. Department of Health and Human Services

Database of Select Committee on GRAS Substances (SCOGS) Reviews

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Taurocholic acid

 
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Report No.:  44
 
Type of Conclusion:  1
 
ID Code:  81-24-3
 
Year:  1975
 
CFR Section:  There is no CFR citation.
 
SCOGS Opinion:  The amounts of the bile acids ingested as constituents of ox bile extract used as a food additive are relatively insignificant, compared to the amounts normally present in the bile of man. The available information indicates that orally administered cholic acid, desoxycholic acid, glycocholic acid, and taurocholic acid are readily absorbed and excreted without accumulation. They exhibit a relatively low toxicity for several animal species tested. The Select Commitee has no information to indicate that the individual bile acids or their salts are used in foods. However, the intake estimates available for ox bile extract, of which bile acids and their salts are major constituents, indicate that average daily consumption of ox bile extract added to foods is small, amounting to 0.1 mg or less. The intake of individuals bile acids or their salts would be, commensurately, very small. Such biological effects as have been reported in animal studies, have been elicited at levels of administration that are several orders of magnitude greater that the levels to which man is now exposed in his daily diet. In the light of the information contained in this report, the Select Commitee concludes that: There is no evidence in the available information on ox bile extraxt, or its constituents cholic acid, desoxycholic acid. glycocholic acid, and taurocholic acid- that demonstrates, or suggests reasonable grounds to suspect, a hazard to the public when they are used at levels that are now current or that might reasonably be expected in future.
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