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U.S. Department of Health and Human Services

Database of Select Committee on GRAS Substances (SCOGS) Reviews

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Clove Bud Extract

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Report No.:  19
Type of Conclusion:  1
ID Code:  8000-34-8
Year:  1973
CFR Section:  184.1257
SCOGS Opinion:  The available information indicates that orally administered eugenol, the principal ingredient of cloves and products derived from them, is readily absorbed and excreted without accumulation. Eugenol exhibits a low degree of toxicity for the several animal species tested, and only at levels far greater than those occurring in foods, does it appear to be able under some conditions to produce irritation of the squamous epithelium of the gastrointestinal tract. It is to be noted that cloves, clove oils and eugenol have long been used topically as analgesics, germicides, and for other purposes. In the light of the foregoing, the Select Committee concludes that: There is no evidence in the available information on cloves, clove oils and their principal constituents, eugenol, that demonstrates or suggests reasonable grounds to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.