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U.S. Department of Health and Human Services

GRAS Notice Inventory
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The inventory of GRAS notices provides information about GRAS notices filed within each year since 1998, when FDA received its first GRAS notice. Once FDA has responded to a GRAS notice, the text of FDA's response will also be available as part of the record for that notice. We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.

Records shown on this page: This page is a partial listing of all records in the database. Additional pages/records are available for selection at the bottom of the page. To view all records in the database select the All button at the bottom of the page. To search for a specific food ingredient, enter the term in the Search Criteria box and select Show Items to display only those records that contain the selected term. To view the text of the agency's response to the GRAS notice, select the text in the FDA's Letter column describing the response. Select the specific GRN number in the GRN No. column to view additional detail about any GRAS notice, including in some cases the submission itself. The agency has removed nondisclosable information from these submissions. All copyrighted information has also been removed and the bibliographic information listed in a reference table at the end of the submission.





     No of Records Found:  468
GRN No.
(select GRN No. for detailed record)		 Substance FDA's Letter
(select to view letter)
218 Bacteriophage P100 preparation from Listeria innocua FDA has no questions
217 Tailored triglycerides containing approximately 12 percent medium-chain fatty acids FDA has no questions
216 Lipase enzyme preparation from Rhizopus oryzae FDA has no questions
215 Actinidia arguta extract FDA has no questions
214 Asparaginase enzyme preparation from Aspergillus niger expressing the asparaginase gene from A. niger FDA has no questions
213 Hydroxypropyl methylcellulose - expanded substitution pattern (HPMC-ESP) FDA has no questions
212 Phospholipase A2 enzyme preparation from Streptomyces violaceruber expressing a gene encoding phospholipase A2 from the same species FDA has no questions
211 Xanthan gum (lower pyruvate levels) FDA has no questions
210 Water soluble tomato concentrate FDA has no questions; some uses may require a color additive listing
209 L-theanine FDA has no questions
208 Erythritol FDA has no questions
207 Barley fiber FDA has no questions
206 Phytosterol esters and diglycerides resulting from transesterification of vegetable oils/fats with phytosterols FDA has no questions
205 Pullulanase enzyme preparation from Bacillus subtilis expressing the pullulanase gene from B. acidopullulyticus FDA has no questions
204 Phospholipase C enzyme preparation from Pichia pastoris expressing a heterologous phospholipase C gene FDA has no questions
203 Erythritol fatty acid esters At notifier's request, FDA ceased to evaluate the notice
202 Polyoxyethanyl-alpha-tocopheryl sebacate (PTS) FDA has no questions
201 Asparaginase enzyme preparation from Aspergillus oryzae expressing the asparaginase gene from A. oryzae FDA has no questions
200 Tailored triglycerides enriched in omega-3 fatty acids from fish oil FDA has no questions
199 Concentrated hydrolyzed milk protein FDA has no questions (additional correspondence available)
198 Bacteriophage P100 preparation from Listeria innocua FDA has no questions
197 Phosphatidylserine FDA has no questions
196 Bovine milk basic protein fraction FDA has no questions
195 Mixed beta-Glucanase and xylanase enzyme preparation from Humicola insolens FDA has no questions
194 Carbon monoxide FDA has no questions
193 Fish oil (predominantly sardine and anchovy); tuna oil FDA has no questions
192 High 2-palmitic vegetable oil FDA has no questions
191 Human lysozyme purified from rice At notifier's request, FDA ceased to evaluate the notice
190 Hydroxypropyl methylcellulose At notifier's request, FDA ceased to evaluate the notice
189 Lactoferrin (human) purified from bovine milk At notifier's request, FDA ceased to evaluate the notice
188 Carbon monoxide At notifier's request, FDA ceased to evaluate the notice
187 L(+) Tartaric acid (alternative method of manufacture) FDA has no questions
186 Soy lecithin enzymatically modified to have increased phosphatidylserine FDA has no questions
185 Concentrated tomato lycopene extract FDA has no questions; some uses may require a color additive listing
184 Isomaltulose FDA has no questions
183 Phospholipase A2 enzyme preparation from Aspergillus niger expressing a gene encoding a porcine phospholipase A2 FDA has no questions
182 Hydrolyzed wheat gluten isolate; pea protein isolate FDA has no questions
181 Phytosterols FDA has no questions
180 Allyl isothiocyanate FDA has no questions
179 Polyglycerol polyricinoleic acid FDA has no questions
178 Sodium iron EDTA FDA has no questions
177 Plant sterol esters FDA has no questions
176 Plant sterols and plant sterol esters from vegetable oils or sterols/stanols from tall oil FDA has no questions
175 Saccharomyces cerevisiae strain ECMo01 with enhanced expression of urea amidolyase FDA has no questions
174 Lysozyme (human) enzyme preparation from rice At notifier's request, FDA ceased to evaluate the notice.
173 Lycopene from Blakeslea trispora FDA has no questions; some uses may require a color additive listing
172 Isomalto-oligosaccharide At notifier's request, FDA ceased to evaluate the notice.
171 Lactobacillus acidophilus, Lactobacillus lactis, and Pediococcus acidilactici FDA has no questions (additional correspondence available)
170 Shrimp-derived chitosan At notifier's request, FDA ceased to evaluate the notice.
169 Bovine globulin At notifier's request, FDA ceased to evaluate the notice.

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