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U.S. Department of Health and Human Services

GRAS Notice Inventory
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The inventory of GRAS notices provides information about GRAS notices filed within each year since 1998, when FDA received its first GRAS notice. Once FDA has responded to a GRAS notice, the text of FDA's response will also be available as part of the record for that notice. We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.

Records shown on this page: This page is a partial listing of all records in the database. Additional pages/records are available for selection at the bottom of the page. To view all records in the database select the All button at the bottom of the page. To search for a specific food ingredient, enter the term in the Search Criteria box and select Show Items to display only those records that contain the selected term. To view the text of the agency's response to the GRAS notice, select the text in the FDA's Letter column describing the response. Select the specific GRN number in the GRN No. column to view additional detail about any GRAS notice, including in some cases the submission itself. The agency has removed nondisclosable information from these submissions. All copyrighted information has also been removed and the bibliographic information listed in a reference table at the end of the submission.





     No of Records Found:  465
GRN No.
(select GRN No. for detailed record)		 Substance FDA's Letter
(select to view letter)
65 Nisin FDA has no questions
64 Egg white lysozyme FDA has no questions
63 Hops beta acids FDA has no questions
62 Chlorine dioxide generated from particles (<30μm) composed of sodium polyphosphate, magnesium sulfate, sodium silicate and sodium chlorite that are incorporated into low density polyethylene (LDPE) food-packaging films, at levels not exceeding 17.5 micrograms chlorite/in2 of finished package film FDA has no questions (additional correspondence available)
61 Plant sterols/Plant sterol esters FDA has no questions
60 Potassium bisulfate FDA has no questions
59 Hydrogenated starch hydrolysate At notifier's request, FDA ceased to evaluate the notice
58 Gum arabic At notifier's request, FDA ceased to evaluate the notice
57 Argon gas FDA has no questions
56 Diacylglycerol oil FDA has no questions
55 Transglutaminase from Streptoverticillium mobaraense FDA has no questions
54 Xylanase derived from Fusarium venenatum carrying a gene encoding xylanase from Thermomyces lanuginosus FDA has no questions
53 Phytosterol esters FDA has no questions
52 Whey mineral concentrate FDA has no questions
51 Cassia gum from Cassia tora/obtusifolia At notifier's request, FDA ceased to evaluate the notice.
50 Bohenin FDA has no questions
49 Bifidobacterium lactis strain Bb12 and Streptococcus thermophilus strain Th4 FDA has no questions (additional correspondence available)
48 Vegetable oil phytosterol esters FDA has no questions
47 Arabinogalactan from Larix occidentalis FDA has no questions
46 Gamma cyclodextrin FDA has no questions
45 Trehalose FDA has no questions
44 Fructooligosaccharide FDA has no questions (additional correspondence available)
43 Lipase derived from Aspergillus oryzae carrying a gene encoding lipase from Thermomyces lanuginosus FDA has no questions (additional correspondence available)
42 Milk-derived lactoferrin Notice does not provide a basis for a GRAS determination (additional correspondence available)
41 DHASCO (docosahexaenoic acid-rich single-cell oil) and ARASCO (arachidonic acid-rich single-cell oil) FDA has no questions
40 Mineral oil Notice does not provide a basis for a GRAS determination
39 Tall oil phytosterols FDA has no questions (additional correspondence available)
38 Cetylpyridinium chloride Notice does not provide a basis for a GRAS determination
37 Whey protein isolate and dairy product solids FDA has no questions (additional correspondence available)
36 Chromium picolinate; Ginkgo biloba leaf extract; and Ginseng extract At notifier's request, FDA ceased to evaluate the notice
35 Hempseed oil Notice does not provide a basis for a GRAS determination
34 Aspartic proteinase derived from Aspergillus oryzae carrying a gene encoding aspartic proteinase from Rhizomucor miehei FDA has no questions
33 Low erucic acid oil derived from Brassica juncea FDA has no questions
32 Pectin lyase derived from Trichoderma reesei carrying a gene encoding pectin lyase from Aspergillus niger FDA has no questions
31 Cetylpyridinium chloride At notifier's request, FDA ceased to evaluate the notice.
30 Crospovidone-cranberry juice extract Notice does not provide a basis for a GRAS determination (additional correspondence available)
29 Transglutaminase from Streptoverticillium mobaraense FDA has no questions
28 Seaweed-derived calcium FDA has no questions (additional correspondence available)
27 Dextranase from Chaetomium gracile FDA has no questions
26 Isolated wheat protein FDA has no questions
25 Extract of Garcinia kola seed ("bitter cola") Notice does not provide a basis for a GRAS determination
24 alpha-Amylase derived from Bacillus licheniformis carrying a gene encoding alpha-amylase from Bacillus stearothermophilus FDA has no questions
23 Protein preparation from animal blood At notifier's request, FDA ceased to evaluate the notice
22 alpha-Amylase derived from Bacillus licheniformis carrying a gene encoding a modified alpha-amylase derived from Bacillus lichenformis and Bacillus amyloliquefaciens FDA has no questions
21 Pork collagen FDA has no questions
20 Pullulanase derived from Bacillus subtilis carrying a gene encoding pullulanase from Bacillus naganoensis FDA has no questions
19 Ferrous bisglycinate chelate FDA has no questions
18 Mesquite (Prosopis spp.) wood alcoholic extract FDA has no questions
17 Arabinogalactan At notifier's request, FDA ceased to evaluate the notice.
16 Menhaden oil At notifier's request, FDA ceased to evaluate the notice

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