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U.S. Department of Health and Human Services

List of Indirect Additives Used in Food Contact Substances
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Please note that by being listed below, no inference should be made about the legality of using any one of these specific substances as an "indirect" food additive. Their presence on this list only indicates that the names of these substances are found (or, in the case of some of the polymers, are implied) in 21CFR parts 175 - 178. The regulation(s) cited for a substance should always be consulted for the complete context before any conclusion is made as to allowed regulated use. To access the specific regulations listed below, type in the title number, 21, and then the section and part numbers, e.g. 175 and 105 at the Government Printing Office web site.

Definitions of the labels that are found in this inventory are:

LabelDefinition
DOCNUMThe PAFA database number
MAINTERMThe name of the substance as recognized by CFSAN
CAS RN OR OTHER CODEChemical Abstract Service (CAS) Registry Number for the substance or a numerical code assigned by CFSAN to those substances that do not have a CAS Registry Number (888nnnnnn or 977nnnnnn-series)
REGNUMRegulation numbers in Title 21 of the U.S. Code of Federal Regulations where the substance appears. (Note that if a substance is mentioned in 21CFR parts 175 - 178 and, thus, is listed below, any other citations for the same substance in other sections of 21CFR dealing with food additives (parts 1 - 199 inclusive) are also cited.)




     No of Records Found:  3,237
Doc No. Mainterm CAS RN or Other Code Regnum
5129 1,4-BIS(BROMOACETOXY)-2-BUTENE 20679-58-7 176.300
5153 1,3-BIS(ISOCYANATOMETHYL)CYCLOHEXANE 38661-72-2 177.1680
5144 BIS(2-ETHYLHEXYL) CYCLOHEXANE-1,2-DICARBOXYLATE 84-71-9 175.105
5140 2,6-BIS((DIMETHYLAMINO)METHYL)CYCLOHEXANONE 2478-21-9 176.300
5138 2,2-BIS(4-(3,4-DICARBOXYPHENOXY)PHENYL)PROPANE DIANHYDRIDE-P-PHENYLENEDIAMINE COPOLYMER 61128-46-9 177.1595
5167 4,4'-BIS(ALPHA, ALPHA-DIMETHYLBENZYL)DIPHENYLAMINE 10081-67-1 175.105
175.300
177.1590
178.2010
8065 5,7-BIS)1,1-DIMETHYLETHYL)-3-HYDROXY-2(3H)-BENZOFURANONE, REACTIONPRODUCTS WITH O-XYLENE 181314-48-7 178.2010
5130 5,5-BIS(BROMOACETOXYMETHYL)-M-DIOXANE 5489-70-3 176.300
5135 BIS(2-CHLOROETHYL) ETHER 111-44-4 176.170
7080 N,N-BIS(2-ETHYLHEXYL)-AR-METHYL-1H-BENZOTRIAZOLE-1-METHANAMINE 94270-86-7 178.3570
5143 BIS(2-ETHYLHEXYL) AZELATE 103-24-2 178.3740
178.3910
8441 BIS(METHOXYMETHYL)ETHYL MALEATE 102054-10-4 175.320
7117 BIS(2,4-DI-TERT-BUTYL-6-METHYL PHENYL) ETHYL PHOSPHITE 145650-60-8 178.2010
5134 BIS(2-CHLOROETHYL) FORMAL 111-91-1 177.1650
5139 BIS(DICHLOROPROPYL) FORMAL 89774-77-6 177.1650
5141 1,2-BIS(3,5-DI-TERT-BUTYL-4-HYDROXYHYDROCINNAMOYL)HYDRAZINE 32687-78-8 175.105
177.2010
5994 N,N-BIS(HYDROGENATED TALLOW ALKYL)-2-AMINOETHANOL 116438-56-3 178.3910
5996 N,N-BIS(2-HYDROXYETHYL)ALKYL(C12-C18)AMIDE 71786-60-2 176.170
176.180
178.3130
7095 N,N-BIS(2-HYDROXYETHYL)ALKYL(C13-15)AMINE 977078-97-9 178.3130
8083 N,N-BIS(2-HYDROXYETHYL)ALKYL(C13-C15)AMINE 70955-14-5 178.3130
5026 N,N-BIS(2-HYDROXYETHYL)ALKYL(C14-18)AMINE 977096-09-5
5200 N,N-BIS(2-HYDROXYETHYL)BUTYLAMINE 102-79-4 178.3910
6753 N,N-BIS(2-HYDROXYETHYL)-N-(CARBOXYMETHYL) OCTADECANAMINUM HYDROXIDE(INNER SALT) 24170-14-7 178.3130
5997 N,N-BIS(HYDROXYETHYL)OCTADECYLAMINE 10213-78-2 178.3130
8476 1,3-BIS(HYDROXYMETHYL)-5,5-DIMETHYLHYDANTOIN 6440-58-0 176.170
5151 BIS(ISOCYANATOMETHYL)BENZENE 25854-16-4 177.1390
177.1680
5152 BIS(ISOCYANATOMETHYL)CYCLOHEXANE 42170-25-2 177.1680
5154 BIS(METHOXYMETHYL)TETRAKIS((OCTADECYLOXY)METHYL)MELAMINE 38413-82-0 176.170
5155 BIS(METHOXYMETHYL)TETRAKIS((OCTADECYLOXY)METHYL)MELAMINE RESIN 68412-27-1 176.170
5125 4,4'-BIS(AMINOCYCLOHEXYL)METHANE CARBAMATE 19262-37-4 177.2600
5156 2,6-BIS(1-METHYLHEPTADECYL)-P-CRESOL 5012-62-4 175.105
178.2010
5147 2,6-BIS((2-HYDROXY-5-METHYL-3-NONYLPHENYL)METHYL)-4-METHYLPHENOL 17201-15-9 178.2010
5616 1,2-BIS(MONOBROMOACETOXY) ETHANE 3785-34-0 176.300
5136 3,3-BIS(CHLOROMETHYL)OXETANE 78-71-7 177.2430
5137 3,3-BIS(CHLOROMETHYL)OXETANE POLYMER 25323-58-4 177.2430
5172 BIS(TRI-N-BUTYLTIN) OXIDE 56-35-9 175.105
5174 BIS(TRIOCTYLTIN) OXIDE 2787-93-1
7618 2,2'-(OXYBIS((METHYL-2,1-ETHANEDIYL)-OXYMETHYLENE))BISOXIRANE 41638-13-5 175.105
8455 2,2'-[(1-METHYLETHYLIDENE)BIS(4,1-PHENYLENEOXY[1-(BUTOXYMETHYL)-2,1-ETHANEDIYL]OXYMETHYLENE)]BISOXIRANE 71033-08-4 175.300
5149 4,4-BIS(4-HYDROXYPHENYL)PENTANOIC ACID 126-00-1 175.300
177.1390
5150 4,4-BIS(4-HYDROXYPHENYL)PENTANOIC ACID, MODIFIED POLYAMIDE RESIN 977139-89-1 175.300
175.320
8480 2-[4,6-BIS(2,4-DIMETHYLPHENYL)-1,3,5-TRIAZIN-2-YL]-5-(OCTYLOXY)PHENOL 2725-22-6 178.2010
5160 BISPHENOL A 80-05-7 175.105
175.300
177.1440
177.1580
177.1585
177.2280
177.2440
177.2800
5164 BISPHENOL A, POLYBUTYLATED 977039-21-6 175.105
177.2600
5165 BISPHENOL B 77-40-7 175.300
5162 BISPHENOL A DIHYDROGEN PHOSPHITE 977041-39-6
5166 BISPHENOL B-EPICHLOROHYDRIN COPOLYMER 9003-88-7 175.105
175.300
177.1390
177.1650
7135 3,6-BIS(4-CHLOROPHENYL)-2,5-DIHYDROPYRROLO(3,4-C)PYRROLE-1,4-DIONE 84632-65-5 178.3297
8436 BIS(2,2,6,6-TETRAMETHYL-4-PIPERIDINYL) SEBACATE 52829-07-9 178.2010
5159 BIS(P-ETHYLBENZYLIDENE)SORBITOL 79072-96-1 178.3295
7121 4,4'-BIS(5-METHYL-2-BENZOXAZOLYL)STILBENE 2397-00-4 178.3297
5295 4,4'-BIS(4-ANILINO-6-DIETHANOLAMINE-ALPHA-TRIAZIN-2-YLAMINO)-2,2'-STILBENE DISULFONIC ACID, DISODIUM SALT 4193-55-9 178.3297
5570 4,4'BIS(4-ANILINO-6-METHYLETHANOLAMINE-ALPHA-TRIAZIN-2-YLAMINO)-2,2'STILBENE DISULFONIC ACID, DISODIUM SALT 13863-31-5 178.3297
5132 BIS(BUTOXYCARBONYLETHYL)TIN DICHLORIDE 61470-33-5
5173 BIS(TRICHLOROMETHYL) SULFONE 3064-70-8 175.105
176.180
176.300
5175 BISULFITE 15181-46-1
7723 P,P'-BIS(UNDECAFLUOROCYCLOHEXANEMETHANOL) PYROPHOSPHATE 48240-25-1 176.170
5169 3,9-BIS(2-(3-(3-TERT-BUTYL-4-HYDROXY-5-METHYLPHENYL)PROPIONYLOXY)-1,1-DIMETHYLETHYL)-2,4,8,10-TETRAOXASPIRO(5.5)UNDECANE 90498-90-1 178.2010
5176 BITOLYLENE DIISOCYANATE 91-97-4
8086 BROMINATED ISOBUTYLENE-ISOPRENE COPOLYMERS 68441-14-5 177.1210
177.2600
5177 4-BROMOACETOXYMETHYL-M-DIOXOLANE 5137-36-0 176.300
5178 2-BROMO-4'-HYDROXYACETOPHENONE 2491-38-5 176.170
176.300
5179 2-BROMO-2-NITRO-1,3-PROPANEDIOL 52-51-7 175.105
176.170
176.180
176.300
5121 BETA-BROMO-BETA-NITROSTYRENE 7166-19-0 176.300
5180 BURNT SIENNA 12000-57-6 178.3297
5181 BUTADIENE 106-99-0 175.105
176.170
176.180
177.1020
177.1030
177.1050
177.1480
177.1635
177.1640
177.1810
177.2600
177.2800
178.3790
5182 BUTADIENE MONOXIDE POLYMER 26703-03-7 175.300
177.1200
177.1390
177.1650
5183 1,3-BUTADIENE-STYRENE POLYMER, HYDROGENATED 977097-69-0 176.180
177.1810
5184 BUTADIENE-VINYLTOLUENE COPOLYMER 9052-61-3 175.300
8285 1,4-BUTANEDIAMINE 110-60-1 177.1500
8483 BUTANEDIOIC ACID, SULFO-1,4-DIISODECYL ESTER, AMMONIUM SALT 144093-88-9 175.105
175.125
176.170
176.180
176.3400
8286 BUTANEDIOL FORMAL 505-65-7 177.2470
5185 BUTENE 25167-67-3 175.105
177.1430
177.2800
5186 1-BUTENE 106-98-9 177.1520
177.1570
177.2600
8287 (E)-2-BUTENEDIOIC ACID 6915-18-0 177.1500
5187 BUTOXYCARBONYLETHYLTIN TRICHLORIDE 61470-34-6
5189 BUTYL ACETYLRICINOLEATE 140-04-5 175.105
177.2600
177.2800
5190 BUTYL ACRYLATE 141-32-2 175.105
175.300
175.320
176.170
176.180
177.1010
177.1200
177.1630
177.2420
178.3790
5191 BUTYLAMINOETHYL METHACRYLATE, TERT- 3775-90-4 177.1010
7150 BUTYLATED REACTION PRODUCT OF P-CRESOL AND DICYCLOPENTADIENE 68610-51-5 175.105
175.125
177.2600
178.2010
5338 BUTYLATED, STYRENATED CRESOLS 977043-19-8 175.105
177.2600
178.2010
5192 BUTYL BENZOATE 136-60-7 175.105
5193 BUTYL BENZYL PHTHALATE 85-68-7 175.105
176.170
176.180
177.2420
178.3740
5194 BUTYL DECYL PHTHALATE 89-19-0 175.105
5195 BUTYLENE GLYCOL 25265-75-2 175.300
176.180
176.210
177.1390
5196 1,4-BUTYLENE GLYCOL 110-63-4 175.105
177.1500
177.1630
177.1660
177.1680
177.2600
7326 1,3-BUTYLENE GLYCOL-DIGLYCOLIC ACID COPOLYMER 9010-84-8 175.105
5197 1,3-BUTYLENE GLYCOL DIMETHACRYLATE 1189-08-8 175.105
177.1010
178.3790
5198 1,4-BUTYLENE GLYCOL DIMETHACRYLATE 2082-81-7 177.1010
5605 BUTYLENE OXIDE 26249-20-7 176.180
176.300
5409 BUTYL FUMARATE 105-75-9 175.105
176.170
176.180
5199 4,4'-BUTYLIDENEBIS(6-TERT-BUTYL-M-CRESOL) 85-60-9 175.105
175.300
177.1632
177.2600
178.2010
5201 BUTYLLITHIUM 109-72-8 177.2600
5411 BUTYL MALEATE 105-76-0 175.105
175.320
176.170
176.180
5202 BUTYL METHACRYLATE 97-88-1 175.105
175.300
175.320
176.170
176.180
177.1010
177.1200
177.1630
177.2420
178.3790
5203 BUTYL OCTYL PHTHALATE 84-78-6 175.105
5204 BUTYL OLEATE 142-77-8 176.170
177.2600
7830 BUTYL OLEATE, SULFATED, POTASSIUM SALT 977170-67-4 172.270
176.170
7831 BUTYL OLEATE, SULFATED, SODIUM SALT 42808-36-6 172.270
176.170
5206 BUTYL PALMITATE 111-06-8 177.2260

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