Information about drug residues and pharmacokinetic parameters in aquatic species is relatively sparse.
In addition, it is difficult to rapidly compare data between studies due to differences in experimental conditions,
such as water temperatures and salinity. To facilitate the study of aquatic species drug metabolism, we constructed a
Fish Drug/Chemical Analysis Phish-Pharm (FDA-PP) database. This database consists of more than 400 articles that include
data from 90 species (64 genera) of fish. This database will be a valuable resource to investigators of drug metabolism in
aquatic species as well as government and private organizations involved in the drug approval process for aquatic species.
Many of the listed compounds are not approved for use in fish in the US. Half-life estimates reported in this database should
not be used to determine withdrawal times. Please note that the raw data supporting the estimates contained in the literature
articles have not been reviewed by the FDA
Title
Authors
Drug
Species
Date
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,3,7,8-Tetrachlorodibenzo-p-dioxin metabolism and disposition in yellow perch. Kleeman JM, Olson JR, Chen SM, Peterson RE (1986b)
TCDD-(2,3,7,8-Tetrachlorodibenzo-p-dioxin)
Perca flavescens
1986
2,4-Dichlorophenoxyacetic acid disposition after oral administration in channel catfish. Plakas SM, Khoo L, Barron MG
DCPA-(2,4-Dichlorophenoxyacetic acid)
Ictalurus punctatus
1992
2,4-Dichlorophenoxyacetic acid disposition after oral administration in channel catfish. Plakas SM, Khoo L, Barron MG
DCPA-(2,4-Dichlorophenoxyacetic acid)
Ictalurus punctatus
1992
A Physiologically Based Pharmacokinetic Model for Predicting the Withdraw Period of Oxytetracycline in Cultured Chinook Salmon (Oncorhynchus tshawytscha). Law FCP (1999)
Oxytetracycline
Oncorhynchus tshawytscha
1999
A Physiologically Based Pharmacokinetic Model for Predicting the Withdraw Period of Oxytetracycline in Cultured Chinook Salmon (Oncorhynchus tshawytscha). Law FCP (1999)
Oxytetracycline
Oncorhynchus tshawytscha
1999
A Physiologically Based Pharmacokinetic Model for Predicting the Withdraw Period of Oxytetracycline in Cultured Chinook Salmon (Oncorhynchus tshawytscha). Law FCP (1999)
Oxytetracycline
Oncorhynchus tshawytscha
1999
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A biologically based toxicokinetic model for pyrene in rainbow trout. Law FC, Abedini S, Kennedy CJ
Pyrene
Oncorhynchus mykiss
1991
A bridging study for oxytetracycline in the edible fillet of rainbow trout: Analysis by a liquid chromatographic method and the official microbial inhibition assay. Stehly GR, Gingerich WH, Kiessling CR, Cutting JH
Oxytetracycline
Oncorhynchus mykiss
1999
A comparative pharmacokinetic study of seven sulphonamides and a sulphonamide potentiator, trimethoprim, in Rainbow trout (Salmo Gairdneri, Richardson). McCarthy DH, Stevenson JP, Salsbury AW
Sulfamethylphenazole
Oncorhynchus mykiss
1974
A comparative pharmacokinetic study of seven sulphonamides and a sulphonamide potentiator, trimethoprim, in Rainbow trout (Salmo Gairdneri, Richardson). McCarthy DH, Stevenson JP, Salsbury AW
Sulfamerazine
Oncorhynchus mykiss
1974
A comparative pharmacokinetic study of seven sulphonamides and a sulphonamide potentiator, trimethoprim, in Rainbow trout (Salmo Gairdneri, Richardson). McCarthy DH, Stevenson JP, Salsbury AW
Sulfadimidine
Oncorhynchus mykiss
1974
A comparative pharmacokinetic study of seven sulphonamides and a sulphonamide potentiator, trimethoprim, in Rainbow trout (Salmo Gairdneri, Richardson). McCarthy DH, Stevenson JP, Salsbury AW
Sulfadiazine
Oncorhynchus mykiss
1974
A comparative pharmacokinetic study of seven sulphonamides and a sulphonamide potentiator, trimethoprim, in Rainbow trout (Salmo Gairdneri, Richardson). McCarthy DH, Stevenson JP, Salsbury AW
Trimethoprim
Oncorhynchus mykiss
1974
A comparative pharmacokinetic study of seven sulphonamides and a sulphonamide potentiator, trimethoprim, in Rainbow trout (Salmo Gairdneri, Richardson). McCarthy DH, Stevenson JP, Salsbury AW
Sulfathiazole
Oncorhynchus mykiss
1974
A comparative pharmacokinetic study of seven sulphonamides and a sulphonamide potentiator, trimethoprim, in Rainbow trout (Salmo Gairdneri, Richardson). McCarthy DH, Stevenson JP, Salsbury AW
Sulfanilamide
Oncorhynchus mykiss
1974
A comparative pharmacokinetic study of seven sulphonamides and a sulphonamide potentiator, trimethoprim, in rainbow trout (Salmo Gairdneri, Richardson). McCarthy DH, Stevenson JP, Salsbury AW
Sulfamethoxypyridazine
Oncorhynchus mykiss
1974
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus tshawytscha
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus tshawytscha
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus tshawytscha
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus tshawytscha
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus tshawytscha
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus mykiss
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus mykiss
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus mykiss
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus mykiss
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus mykiss
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus mykiss
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus mykiss
1999
A comparative tissue distribution study of oxytetracycline in rainbow trout, Oncorhynchus mykiss (Walbaum), and chinook salmon, Oncorhynchus tshawytscha (Walbaum). Namdari R, Abedini S, Law FCP (1999)
Oxytetracycline
Oncorhynchus mykiss
1999
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