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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed within each year since 1998, when FDA received its first GRAS notice. Once FDA has responded to a GRAS notice, the text of FDA's response will also be available as part of the record for that notice. We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 550 Show All Page 1 of 11
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
550 Meso-zeaxanthin Pending
549 Sodium salts of fatty acids from Mortierella alpina oil Pending
548 High purity rebaudioside D Pending
547 Lacto-N-neotetraose Pending
546 2'-O-fucosyllactose Pending
545 Phosphatidylserine derived from sunflower Pending
544 β-glucans from oat bran Pending
543 Lutein esters Pending
542 Lutein Pending
541 Insoluble fiber from citrus peel Pending
540 Soybean leghemoglobin from Pichia pastoris Pending
539 Fish oil Pending
538 Cane juice extract Pending
537 Short-chain fructo-oligosaccharides Pending
536 High purity rebaudioside C Pending
535 Beta-glucanase from Streptomyces violaceoruber Pending
534 Hydrogenated lecithin from soy Pending
533 Lecithin from canola Pending
532 Iron complex of tartaric acid Pending
531 Lactobacillus fermentum CECT5716 Pending
530 Extract of Apocynum venetum leaves Pending
529 Seed from Phalaris canariensis L. (canary grass) Pending
528 Preparation containing six bacterial monophages (LIST-36, LMSP-25, LMTA-34, LMTA-57, LMTA-94 and LMTA-148) specific to Listeria monocytogenes Pending
527 Algal oil (87% oleic acid) derived from Prototheca moriformis strain S2532 Pending
526 Bacillus coagulans strain Unique IS2 spores preparation Pending
525 Pea fiber Sep 25, 2014 FDA has no questions
524 Phospholipase A2 enzyme preparation from Trichoderma reesei carrying a phospholipase A2 gene from Aspergillus nishimurae Pending
523 l-leucine Pending
522 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Pending
521 Congugated linoleic acid isomers Pending
520 Hydrogen gas Pending
519 Chlorella protothecoides strain S106 flour with 40-75% protein Pending
518 Galacto-oligosaccharides Pending
517 Natamycin Pending
516 Steviol glycosides with rebaudioside A and stevioside as the principal components Oct 30, 2014 FDA has no questions
515 D-beta-hydroxybutyrate ester Pending
514 Sucrose fatty acid esters Pending
513 Dried biomass of Euglena gracilis containing beta-1,3-glucan from Euglena gracilis Jul 10, 2014 At the notifier's request, FDA ceased to evaluate the notice
512 High purity Rebaudioside M Oct 24, 2014 FDA has no questions
511 Citric acid esters of mono- and diglycerides Pending
510 Acid lactase from Aspergillus oryzae expressed in Aspergillus niger Sep 29, 2014 FDA has no questions
509 Glucose oxidase enzyme preparation derived from Penicillium chrysogenum Pending
508 Salts from dried mineral water (65% NaCl) Pending
507 Amylomaltase enzyme preparation from Bacillus amyloliquefaciens carrying an amylomaltase gene from Thermus thermophiles Sep 11, 2014 FDA has no questions
506 Sacha inchi oil, a vegetable oil derived from Plukenetia volubilis. Sep 10, 2014 FDA has no questions
505 Phosphodiesterase I enzyme preparation from Leptographium procerum Aug 12, 2014 FDA has no questions
504 Concentrated milk proteins Pending
503 Tamarind seed polysaccharide Aug 12, 2014 FDA has no questions
502 Lactobacillus acidophilus La-14 Aug 19, 2014 FDA has no questions
501 L-theanine (chemically synthesized) Sep 10, 2014 FDA has no questions

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
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