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U.S. Department of Health and Human Services

GRAS Notices

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The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.

We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.


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  • Select the specific GRN number below to view additional details about any GRAS Notice.
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Records Found: 678 Show All Page 1 of 14
GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
678 Alpha-cyclodextrin Pending
677 Docosahexaenoic acid oil produced in Schizochytrium sp. Pending
676 Colicin Pending
675 Xylanase from Trichoderma reesei produced in Talaromyces leycettanus Pending
674 Isomalto-oligosaccharides Pending
673 Algal fat derived from Prototheca moriformis (S7737) Pending
672 Preparation containing five bacterial monophages specific to Shigella spp. Pending
671 Galacto-oligosaccharides (GOS) Pending
670 Inactivated Bacillus coagulans GBI-30, 6086 Pending
669 Cow’s milk-derived lactoferrin Pending
668 Sodium formate Pending
667 Rebaudioside M Pending
666 Chondroitin sodium sulfate Pending
665 Lactoperoxidase system Pending
664 Alpha-amylase from Cytophaga sp. expressed in Bacillus licheniformis Pending
663 Distarch phosphate Pending
662 Glucosylated steviol glycosides (minimum purity 95%) Sep 29, 2016 FDA has no questions
661 Fucus vesiculosus concentrate Pending
660 Bacillus coagulans GBI-30, 6086 Pending
659 Lacto-N-neotetraose Pending
658 Grapefruit extract Pending
657 Glucoamylase from Penicillum oxalicum produced in Aspergillus niger Pending
656 Enzyme-modified steviol glycosides Sep 28, 2016 FDA has no questions
655 Rice bran wax Pending
654 Cocoa butter substitute Pending
653 Lysophospholipase from Aspergillus nishimurae expressed in Trichoderma reesei. Pending
652 Gamma linolenic acid safflower oil Pending
651 Phospholipase A1 from Talaromyces leycettanus produced in Aspergillus niger Pending
650 2'-O-fucosyllactose Pending
649 β-galactosidase enzyme preparation from Bacillus circulans produced in Bacillus subtilis Pending
648 Monoglycerides Pending
647 D-psicose Pending
646 Pecan shell fiber Pending
645 Pullulanase from Bacillus deramificans and Bacillus acidopullulyticus expressed in Bacillus licheniformis Pending
644 Non-fat dry goat milk and goat whey protein Pending
643 Phosphatidylserine derived from fish Jul 1, 2016 At the notifier's request, FDA ceased to evaluate this notice
642 Camelina oil Pending
641 Pyrroloquinoline quinone disodium salt Pending
640 Esterified propoxylated glycerol Sep 21, 2016 FDA has no questions
639 Zeaxanthin from marigold Pending
638 High purity steviol glycosides (minimum purity 97%) consisting primarily of rebaudioside A Jul 10, 2016 FDA has no questions
637 Phosphatidylserine derived soy lecithin Aug 4, 2016 At the notifier's request, FDA ceased to evaluate this notice
636 Phosphatidylserine derived from sunflower Jul 1, 2016 At the notifier's request, FDA ceased to evaluate this notice
635 Nicotinamide riboside chloride Aug 3, 2016 FDA has no questions
634 Calcium chloride Pending
633 Whey protein Sep 21, 2016 FDA has no questions
632 Rebaudioside A from Yarrowia lipolytica Jun 24, 2016 FDA has no questions
631 Triacylglycerol lipase from Fusarium oxysporum produced in Trichoderma reesei Pending
630 Preparation containing the bacterial monophages, Fo1a and S16, specific to Salmonella May 17, 2016 At the notifier's request, FDA ceased to evaluate this notice
629 Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract Jul 15, 2016 At the notifier's request, FDA ceased to evaluate this notice

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GRN No.
(sorted Z-A)
Substance Date of closure FDA's Letter
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