The inventory of GRAS notices provides information about GRAS notices filed since 1998, when FDA received its first GRAS notice. As of October 17, 2016, the GRAS final rule (81 FR 54960; August 17, 2016) requires a specific format for a GRAS notice. Prior to that date, FDA processed GRAS notices under the framework of the GRAS proposed rule (62 FR 18938; April 17, 1997). Notices received prior to the effective date of the GRAS final rule provide examples for potential notifiers for the types of information that may support a GRAS conclusion. In the inventory, notices follow the requirements for the format and content of a GRAS notice as of the effective date of the GRAS final rule.
We will update this information approximately monthly. More information about this inventory is available on the GRAS Notice Inventory Introduction page.
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|Substance||Date of closure||FDA's Letter|
|677||Docosahexaenoic acid oil produced in Schizochytrium sp.||Pending|
|675||Xylanase from Trichoderma reesei produced in Talaromyces leycettanus||Pending|
|673||Algal fat derived from Prototheca moriformis (S7737)||Pending|
|672||Preparation containing five bacterial monophages specific to Shigella spp.||Pending|
|670||Inactivated Bacillus coagulans GBI-30, 6086||Pending|
|669||Cow’s milk-derived lactoferrin||Pending|
|666||Chondroitin sodium sulfate||Pending|
|664||Alpha-amylase from Cytophaga sp. expressed in Bacillus licheniformis||Pending|
|662||Glucosylated steviol glycosides (minimum purity 95%)||Sep 29, 2016||FDA has no questions|
|661||Fucus vesiculosus concentrate||Pending|
|660||Bacillus coagulans GBI-30, 6086||Pending|
|657||Glucoamylase from Penicillum oxalicum produced in Aspergillus niger||Pending|
|656||Enzyme-modified steviol glycosides||Sep 28, 2016||FDA has no questions|
|655||Rice bran wax||Pending|
|654||Cocoa butter substitute||Pending|
|653||Lysophospholipase from Aspergillus nishimurae expressed in Trichoderma reesei.||Pending|
|652||Gamma linolenic acid safflower oil||Pending|
|651||Phospholipase A1 from Talaromyces leycettanus produced in Aspergillus niger||Pending|
|649||β-galactosidase enzyme preparation from Bacillus circulans produced in Bacillus subtilis||Pending|
|646||Pecan shell fiber||Pending|
|645||Pullulanase from Bacillus deramificans and Bacillus acidopullulyticus expressed in Bacillus licheniformis||Pending|
|644||Non-fat dry goat milk and goat whey protein||Pending|
|643||Phosphatidylserine derived from fish||Jul 1, 2016||At the notifier's request, FDA ceased to evaluate this notice|
|641||Pyrroloquinoline quinone disodium salt||Pending|
|640||Esterified propoxylated glycerol||Sep 21, 2016||FDA has no questions|
|639||Zeaxanthin from marigold||Pending|
|638||High purity steviol glycosides (minimum purity 97%) consisting primarily of rebaudioside A||Jul 10, 2016||FDA has no questions|
|637||Phosphatidylserine derived soy lecithin||Aug 4, 2016||At the notifier's request, FDA ceased to evaluate this notice|
|636||Phosphatidylserine derived from sunflower||Jul 1, 2016||At the notifier's request, FDA ceased to evaluate this notice|
|635||Nicotinamide riboside chloride||Aug 3, 2016||FDA has no questions|
|633||Whey protein||Sep 21, 2016||FDA has no questions|
|632||Rebaudioside A from Yarrowia lipolytica||Jun 24, 2016||FDA has no questions|
|631||Triacylglycerol lipase from Fusarium oxysporum produced in Trichoderma reesei||Pending|
|630||Preparation containing the bacterial monophages, Fo1a and S16, specific to Salmonella||May 17, 2016||At the notifier's request, FDA ceased to evaluate this notice|
|629||Siraitia grosvenorii Swingle (Luo Han Guo) fruit extract||Jul 15, 2016||At the notifier's request, FDA ceased to evaluate this notice|
|Substance||Date of closure||FDA's Letter|