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Infect Immun 2005 Feb;73(2):1196-203

Long-term protection against tuberculosis following vaccination with a severely attenuated double lysine and pantothenate auxotroph of Mycobacterium tuberculosis.

Sambandamurthy VK, Derrick SC, Jalapathy KV, Chen B, Russell RG, Morris SL, Jacobs WR Jr

Jacobs WR, Albert Einstein Coll Med, Howard Hughes Med Inst, 1300 Morris Pk Ave, Bronx, NY 10461 USA Albert Einstein Coll Med, Howard Hughes Med Inst, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA Georgetown Univ, Dept Pathol, Lombardi Canc Ctr, Washington, DC USA US FDA, Ctr Biol Evaluat & Res, Bethesda, MD USA

Abstract

We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The DeltalysA DeltapanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.


Category: Journal Article, Peer
PubMed ID: #15664964
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29
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