Scientific Publications by FDA Staff
Haematologica 2006 Aug;91(8):1126-9
Expression of cellular prion protein on platelets from patients with gray platelet or Hermansky-Pudlak syndrome and the protein's association with alpha-granules.
Holada K, Glierova H, Simak J, Vostal JG
Holada K, Charles Univ, Inst Microbiol & Immunol, Fac Med 1, Studnickova 7, Prague 12820 2, Czech Republic Charles Univ, Inst Microbiol & Immunol, Fac Med 1, Prague 12820 2, Czech Republic US FDA, Div Hematol, CBER, Bethesda, MD 20014 USA
The cellular prion protein (PrPc) is a membrane glycoprotein expressed on many human cells including platelets. We investigated the cellular localization of platelet PrPc. In resting platelets most PrPc was localized inside the cells. The correlation of PrPc and P-selectin surface up-regulation after platelet activation suggested its association with alpha-granules. This was confirmed by normal expression of PrPc on Hermansky-Pudlak syndrome platelets, which lack dense granules, and failure of gray platelet syndrome platelets, which lack alpha-granules, to up-regulate PrPc. Our results warrant further studies on the role of platelet PrPc in the transmission of prion diseases by blood transfusion.
|Category: Journal Article|
|PubMed ID: #16885055|
|Includes FDA Authors from Scientific Area(s): Biologics|
|Entry Created: 2011-10-04||Entry Last Modified: 2012-08-29|