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Clin Infect Dis 2008 May 15;46(10):1555-61

Severe eczema vaccinatum in a household contact of a smallpox vaccinee

Vora S, Damon I, Fulginiti V, Weber SG, Kahana M, Stein SL, Gerber SI, Garcia-Houchins S, Lederman E, Hruby D, Collins L, Scott D, Thompson K, Barson JV, Regnery R, Hughes C, Daum RS, Li Y, Zhao H, Smith S, Braden Z, Karem K, Olson V, Davidson W, Trindade G, Bolken T, Jordan R, Tien D, Marcinak J

Vora, S (reprint author), Univ Chicago, Med Ctr, Dept Pediat, Infect Dis Sect, 5841 S Maryland Ave, Chicago, IL 60637 USA Univ Chicago, Med Ctr, Dept Pediat, Infect Dis Sect, Chicago, IL 60637 USA Univ Chicago, Med Ctr, Sect Crit Care, Dept Pediat, Chicago, IL 60637 USA Univ Chicago, Med Ctr, Infect Control Program, Chicago, IL 60637 USA Univ Chicago, Med Ctr, Dermatol Sect, Chicago, IL 60637 USA Univ Chicago, Med Ctr, Dept Pathol, Chicago, IL 60637 USA Chicago Dept Publ Hlth, Chicago, IL USA Ctr Dis Control & Prevent, Poxvirus & Rabies Branch, Atlanta, GA USA Ctr Dis Control & Prevent, Div Bioterrorism Preparedness & Response, Atlanta, GA USA Univ Arizona, Tucson, AZ USA Univ Colorado, Denver, CO 80202 USA SIGA Technol, Corvallis, OR USA US FDA, Washington, DC 20204 USA

Abstract

Background. We report the first confirmed case of eczema vaccinatum in the United States related to smallpox vaccination since routine vaccination was discontinued in 1972. A 28-month-old child with refractory atopic dermatitis developed eczema vaccinatum after exposure to his father, a member of the US military who had recently received smallpox vaccine. The father had a history of inactive eczema but reportedly reacted normally to the vaccine. The child's mother also developed contact vaccinia infection.


Category: Journal Article
PubMed ID: #18419490
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29
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