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Bioorg Med Chem Lett 2009 Apr 15;19(8):2162-7

Synthesis and antiviral activities of novel acylhydrazone derivatives targeting HIV-1 capsid protein.

Tian B, He M, Tang S, Hewlett I, Tan Z, Li J, Jin Y, Yang M

Abstract

HIV-1 capsid protein (CA) plays important roles in the viral replication cycle. A number of acylhydrazone derivatives that act as inhibitors of HIV-1 CA assembly, were designed and synthesized. The synthesized compounds were tested for their antiviral activities and cytotoxicities using CEM cells. Some derivatives also were assayed for their ability to inhibit HIV-1 CA assembly in vitro. Among them, compounds 14f and 14i display the most promising potency with EC(50) values of 0.21 and 0.17 microM respectively.


Category: Journal Article
PubMed ID: #19297155 DOI: 10.1016/j.bmcl.2009.02.116
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29
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