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Nano Lett 2009 Sep;9(9):3312-7

Carbon nanotubes activate blood platelets by inducing extracellular Ca(2+) influx sensitive to calcium entry inhibitors.

Semberova J, De Paoli Lacerda SH, Simakova O, Holada K, Gelderman MP, Simak J

Abstract

To elucidate a mechanism of prothrombotic effects of carbon nanotubes (CNTs), we report here that multiwalled CNTs activate blood platelets by inducing extracellular Ca(2+) influx that could be inhibited by calcium channel blockers SKF 96365 and 2-APB. We also demonstrate platelet aggregating activity of different single-walled and multiwalled CNTs. In addition, we show that CNT-induced platelet activation is associated with a marked release of platelet membrane microparticles positive for the granular secretion markers CD62P and CD63.

Category: Journal Article
PubMed ID: #19736974 DOI: 10.1021/nl901603k
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29
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