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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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J Recept Signal Transduct Res 2009;29(3-4):202-10

Interrogation of phosphor-specific interaction on a high-throughput label-free optical biosensor system-Epic system.

Wu M, Long S, Frutos AG, Eichelberger M, Li M, Fang Y


The Epic system, a high-throughput label-free optical biosensor system, is applied for the biochemical interrogation of phosphor-specific interactions of the 14-3-3 protein and its substrates. It has shown the capability not only for high-throughput characterization of binding rank and affinity but also for the exploration of potential interacting kinases for the substrates. A perspective of biochemical applications for diagnostics and biomarker discovery, as well as cell-based applications for endogenous receptors and viral infection characterization, are also provided.

Category: Journal Article
PubMed ID: #19640222 DOI: 10.1080/10799890903068474
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-04 Entry Last Modified: 2012-08-29