Scientific Publications by FDA Staff
Chem Biol Drug Des 2011 Mar;77(3):189-98
Synthesis and Antiviral Evaluation of New N-acylhydrazones Containing Glycine Residue.
Tian B, He M, Tan Z, Tang S, Hewlett I, Chen S, Jin Y, Yang M
N-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods. Antiviral activity demonstrated that compound 8c bearing 4-methylphenyl moiety was the most active with low cytotoxicity.
|Category: Journal Article|
|PubMed ID: #21306567||DOI: 10.1111/j.1747-0285.2010.01050.x|
|Includes FDA Authors from Scientific Area(s): Biologics|
|Entry Created: 2011-10-03||Entry Last Modified: 2012-08-29|