Scientific Publications by FDA Staff

Chem Biol Drug Des 2011 Mar;77(3):189-98

Synthesis and Antiviral Evaluation of New N-acylhydrazones Containing Glycine Residue.

Tian B, He M, Tan Z, Tang S, Hewlett I, Chen S, Jin Y, Yang M

N-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods. Antiviral activity demonstrated that compound 8c bearing 4-methylphenyl moiety was the most active with low cytotoxicity.