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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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J Virol 2011 Mar;85(6):3030-2

Spread of herpes simplex virus to the spinal cord is independent of spread to dorsal root ganglia.

Ohashi M, Bertke AS, Patel A, Krause PR


Levels of herpes simplex virus 1 (HSV-1) and HSV-2 DNA in dorsal root ganglia (DRG) and spinal cord (SC) were quantified after inoculation of guinea pig genitals and footpads. In genital infection, viral DNA reached SC and DRG simultaneously (at 2 to 3 days after inoculation) but was more abundant in SC than in DRG. After inoculation of footpads, which lack parasympathetic innervation, the viruses spread more efficiently to DRG than to SC. These results show important differences between genital and footpad infections, including independence of spread to DRG and SC, and imply that autonomic neurons may play an important role in the pathogenesis of viral latency after genital inoculation.

Category: Journal Article
PubMed ID: #21159869 DOI: 10.1128/JVI.02426-10
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2011-10-03 Entry Last Modified: 2012-08-29