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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Immunotherapy 2012 Apr;4(4):443-51

IL-13 receptor-directed cancer vaccines and immunotherapy.

Nakashima H, Husain SR, Puri RK


Many immunotherapy approaches including therapeutic cancer vaccines targeting specific tumor-associated antigens are at various stages of development. Although the significance of overexpression of (IL-13Ralpha2) in cancer is being actively investigated, we have reported that IL-13Ralpha2 is a novel tumor-associated antigen. The IL-13Ralpha2-directed cancer vaccine is one of the most promising approaches to tumor immunotherapy, because of the selective expression of IL-13Ralpha2 in various solid tumor types but not in normal tissues. In this article, we will summarize its present status and potential strategies to improve IL-13Ralpha2-directed cancer vaccines for an optimal therapy of cancer.

Category: Journal Article, Review
PubMed ID: #22512637 DOI: 10.2217/IMT.12.28
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2012-04-20 Entry Last Modified: 2012-08-29