Scientific Publications by FDA Staff
Pediatrics 2012 Jul;130(1):23-31
Trends of Outpatient Prescription Drug Utilization in US Children, 2002-2010.
Chai G, Governale L, McMahon AW, Trinidad JP, Staffa J, Murphy D
OBJECTIVE:To describe trends in outpatient prescription drug utilization in US children and the changes in major areas of pediatric therapeutic use for the years 2002 through 2010.METHODS:Large prescription databases (the IMS Vector One: National and Total Patient Tracker) were used to examine national drug utilization patterns for the US pediatric population (ages 0-17 years) from 2002 through 2010.RESULTS:In 2010, a total of 263.6 million prescriptions were dispensed to the US pediatric population, 7% lower than in 2002, while prescriptions dispensed to the adult population increased 22% during the same time. Analysis of pediatric drug utilization trends for the top 12 therapeutic areas in 2010 compared with 2002 showed decreases in systemic antibiotics (-14%), allergies (-61%), pain (-14%), depression (-5%), and cough/cold without expectorant (-42%) prescriptions, whereas asthma (14%), attention-deficit/hyperactivity disorder (46%), and contraceptive (93%) prescriptions increased. In 2010, amoxicillin was the most frequently dispensed prescription in infants (aged 0-23 months) and children (aged 2-11 years). Methylphenidate was the top prescription dispensed to adolescents (aged 12-17 years). Off-label use was identified, particularly for lansoprazole; approximately 358 000 prescriptions were dispensed in 2010 for infants <1 year old.CONCLUSIONS:Changes in the patterns of pediatric drug utilization were observed from 2002 to 2010. Changes include a decrease in antibiotic use and an increase in attention-deficit/hyperactivity disorder medication use during the examined time. This article provides an overview of pediatric outpatient drug utilization, which could set the stage for further in-depth analyses.
|Category: Journal Article|
|PubMed ID: #22711728||DOI: 10.1542/peds.2011-2879|
|Includes FDA Authors from Scientific Area(s): Drugs Women's Health|
|Entry Created: 2012-06-20||Entry Last Modified: 2012-09-11|