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Food Chem Toxicol 2013 Jan;51:149-59

Carcinogenicity of acrylamide in B6C3F(1) mice and F344/N rats from a two-year drinking water exposure.

Beland FA, Mellick PW, Olson GR, Mendoza MC, Matilde Marques M, Doerge DR

Abstract

Acrylamide is a component of roasted coffee and certain baked and fried carbohydrate-rich foods prepared at high temperatures. We have assessed the carcinogenicity of acrylamide in male and female B6C3F1 mice and F344/N rats administered 0, 0.0875, 0.175, 0.35, or 0.70 mM acrylamide in the drinking water ad libitum for two years. Acrylamide caused significant dose-related decreasing trends in the body weights of F344/N rats. Acrylamide administration resulted in significant dose-related decreasing trends in survival in both sexes of B6C3F1 mice and in female F344/N rats. Histopathological analyses indicated significant dose-related increases in Harderian gland and lung tumors in male and female B6C3F1 mice. Male B6C3F1 mice also had a significantly increased incidence of forestomach tumors, while female B6C3F1 mice had significant dose-related increases in mammary gland, ovary, and skin tumors. In male and female F344/N rats, there were significant increases in thyroid tumors. Male F344/N rats also had significant dose-related increases in testes, heart, and pancreas tumors, while female F344 rats demonstrated significant increases in clitoral gland, mammary gland, oral cavity, and skin tumors. These results, combined with previous mechanistic studies, provide strong support for the concept that acrylamide is activated to a carcinogen through metabolism to glycidamide.


Category: Journal Article
PubMed ID: #23009883 DOI: 10.1016/j.fct.2012.09.017
Includes FDA Authors from Scientific Area(s): Toxicological Research
Entry Created: 2012-09-27 Entry Last Modified: 2013-10-17
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