• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

  • Print
  • Share
  • E-mail

Search Publications



Starting Date

Ending Date

Order by

Entry Details

Drug Info J 1997 Apr;31(2):471-87

An Age-Adjusted Trend Test for the Tumor Incidence Rate for Single-Sacrifice Experiments

Kodell RL, Pearce BA, Turturro A, Ahn H


The nonparametric age-adjusted test proposed by Kodell and Ahn (1) for assessing dose-related trend with respect to the tumor incidence rate in animal experiments is extended from the case of multiple sacrifices to the case of a single (terminal) sacrifice. The tumor incidence rate is made identifiable for time intervals preceding the final time interval by assuming constant proportionality of the tumor prevalences in live and dead animals. Information on cause of death is not required. A Monte Carlo simulation study is conducted to assess size and power of the test.

Category: Journal Article
DOI: 10.1177/009286159703100218
Includes FDA Authors from Scientific Area(s): Toxicological Research
Entry Created: 2012-10-24