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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Microb Pathog 2012 Dec 13;55C:9-15

Influenza and respiratory syncytial virus (RSV) vaccines for infants: safety, immunogenicity, and efficacy.

Beeler JA, Eichelberger MC


Respiratory viral infections in infants and young children frequently cause illness that can easily progress to hospitalization and death. There are currently no licensed vaccines to prevent respiratory viral disease in children younger than 6 months, reflecting safety concerns and the difficulty in inducing effective immune responses in infants. This review discusses vaccines that have been developed, or are currently being developed, against influenza and respiratory syncytial virus, with a focus on studies performed to demonstrate their safety and efficacy, and the impact of immunologic immaturity and maternal antibodies on the infant response to vaccines.

Category: Journal Article, Review
PubMed ID: #23247146 DOI: 10.1016/j.micpath.2012.11.013
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2012-11-19 Entry Last Modified: 2013-07-09