• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

  • Print
  • Share
  • E-mail
-

Search Publications



Fields



Centers











Starting Date


Ending Date


Order by

Entry Details

Talanta 2012 Nov 15;101:537-40

Determination of total leachable bisphenol A from polysulfone membranes based on multiple consecutive extractions.

Cho S, Choi YS, Luu HM, Guo J

Abstract

The paper presents the development of a multiple consecutive extraction method enabling the determination of the total amount of bisphenol A (BPA) released from porous polysulfone (PS) membranes in a hemodialyzer or hemoconcentrator under simulated-use conditions. The levels of BPA were determined using solid phase extraction (SPE) coupled with high performance liquid chromatography-mass spectrometry (HPLC-MS). We demonstrated that it was difficult to determine the total amount of BPA released from the PS membranes using a single extraction method with finite solvent volume because of the chemical equilibrium between the extraction solution and the polymer phase. Repeated extractions gave more accurate results than a single extraction for the determination of the total amount of leachables in porous membranes. A general equation was derived to fit the elution profile of BPA released during multiple consecutive extractions.


Category: Journal Article
PubMed ID: #23158360 DOI: 10.1016/j.talanta.2012.09.033
Includes FDA Authors from Scientific Area(s): Medical Devices
Entry Created: 2012-11-21
Feedback
-
-