Scientific Publications by FDA Staff
Talanta 2012 Nov 15;101:537-40
Determination of total leachable bisphenol A from polysulfone membranes based on multiple consecutive extractions.
Cho S, Choi YS, Luu HM, Guo J
The paper presents the development of a multiple consecutive extraction method enabling the determination of the total amount of bisphenol A (BPA) released from porous polysulfone (PS) membranes in a hemodialyzer or hemoconcentrator under simulated-use conditions. The levels of BPA were determined using solid phase extraction (SPE) coupled with high performance liquid chromatography-mass spectrometry (HPLC-MS). We demonstrated that it was difficult to determine the total amount of BPA released from the PS membranes using a single extraction method with finite solvent volume because of the chemical equilibrium between the extraction solution and the polymer phase. Repeated extractions gave more accurate results than a single extraction for the determination of the total amount of leachables in porous membranes. A general equation was derived to fit the elution profile of BPA released during multiple consecutive extractions.
|Category: Journal Article|
|PubMed ID: #23158360||DOI: 10.1016/j.talanta.2012.09.033|
|Includes FDA Authors from Scientific Area(s): Medical Devices|
|Entry Created: 2012-11-21|