Scientific Publications by FDA Staff
J Pharm Sci 1974 Dec;63(12):1946-7
Dose-response predictability of urinary bladder hyperplasia by N-2-fluorenylacetamide feeding in mice: its modification by sex.
Haley TJ, Schieferstein G, Jaques WE, Farmer J, Frith C, Sprawls RW
A serial sacrifice experiment involving urinary bladder hyperplasia, produced by feeding 8¿86 ppm of N-2-fluorenylace-tamide for 90 days to BALB/c mice, showed a dose¿response relationship for males but not females. The information from this study was used in a statistical design to predict the percent of hyperplasia in relation to time and dose. A formula for establishing the confidence limits of the curve was derived. Sex-dependent spontaneous pericardial fibrosis and mineralization were also observed, with the male response being twice that of the female.
|Category: Journal Article|
|PubMed ID: #4449029||DOI: 10.1002/jps.2600631227|
|Includes FDA Authors from Scientific Area(s): Toxicological Research|
|Entry Created: 2012-11-28|