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J Immunogenet 1981 Feb;8(1):73-6

Differential susceptibility of spleen cells from C3/HeN (H-2k) and C3HfB/HeN (H-2kv1) mouse strains to cytotoxicity by monoclonal anti-Kk antibody (clone 11-4).

Martin WJ, Imamura M

Abstract

Spleen cells from C3HfB/HeN mice (H-2kv1) were markedly less susceptible to lysis by monoclonal anti-Kk antibody (Clone 11-4) than spleen cells from C3H/HeN mice (H-2k). Less than 50% of C3HfB/HeN cells were lysed even at the highest antibody concentration tested compared to 70% of C3H/HeN cells. The difference in end point titre of the antibody tested on cells from the two strains was 5-10-fold. Similar differences were not observed using the conventional H-2Kk-typing antiserum (D-23).


Category: Journal Article
PubMed ID: #7252225 DOI: 10.1111/j.1744-313X.1981.tb01074.x
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2012-12-08
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