Scientific Publications by FDA Staff
Biol Mass Spectrom 1981 Aug;8(8):327-31
Derivatization of beta-propiolactone in biological mixtures for enhanced gas chromatographic mass spectrometric determinations
Phillips LR, Fraser BA
Detection and identification of low levels (¿200 ppb) of free ß-propiolactone in complex biological mixtures were achieved through in situ chemical derivatization and subsequent gas chromatographic mass spectrometric determination of the products. ß-Propiolactone, when reacted with octadecylamine, followed by trimethylsilylation, yielded a derivative which exhibited both good gas chromatographic characteristics and highly interpretable mass spectrometric data.
|Category: Journal Article|
|Includes FDA Authors from Scientific Area(s): Biologics|
|Entry Created: 2012-12-08|