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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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Biol Mass Spectrom 1981 Aug;8(8):327-31

Derivatization of beta-propiolactone in biological mixtures for enhanced gas chromatographic mass spectrometric determinations

Phillips LR, Fraser BA


Detection and identification of low levels (¿200 ppb) of free ß-propiolactone in complex biological mixtures were achieved through in situ chemical derivatization and subsequent gas chromatographic mass spectrometric determination of the products. ß-Propiolactone, when reacted with octadecylamine, followed by trimethylsilylation, yielded a derivative which exhibited both good gas chromatographic characteristics and highly interpretable mass spectrometric data.

Category: Journal Article
DOI: 10.1002/bms.1200080802
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2012-12-08