Scientific Publications by FDA Staff
J Immunogenet 1981 Dec;8(6):459-62
Murine immune memory to a TI-2 antigen, DNP-Ficoll: carrier-specificity, genetic enhancement and phenotypic dominant inheritance.
Schott CF, Lizzio EF, Merchant B
C3H/HeN x NZB/BIN F1 mice were primed and challenged with DNP-Ficoll, a thymic independent (TI-2) antigen. They developed strong IgM and IgG carrier-specific memory responses: DNP-pneumococcal polysaccharide or DNP-haemocyanin challenge did not elicit memory responses. The IgG response component appeared to be inherited dominantly from the C3H/HeN parent. The IgM component resulted from genetic enhancement.
|Category: Journal Article|
|PubMed ID: #7334216||DOI: 10.1111/j.1744-313X.1981.tb00953.x|
|Includes FDA Authors from Scientific Area(s): Biologics|
|Entry Created: 2012-12-09|