Scientific Publications by FDA Staff
J Med Virol 1982;10(1):65-74
Immunogenicity in chimpanzees of experimental hepatitis B vaccines prepared from intact hepatitis B virus, purified polypeptides, or polypeptide micelles.
Tabor E, Howard CR, Skelly J, Snoy P, Goudeau A, Zuckerman AJ, Gerety RJ
The immunogenicity of three experimental hepatitis B vaccines was evaluated in chimpanzees. Although no antibody to hepatitis B surface antigen (anti-HBs) was detected in two chimpanzees that received an aqueous polypeptide vaccine subcutaneously, a strong anti-HBs response was observed two and ten weeks, respectively, following challenge with hepatitis B virus. Inoculation of two additional chimpanzees with a micellar preparation of these polypeptides by the intravenous route resulted in anti-HBs production in one of the chimpanzees. Two chimpanzees inoculated subcutaneously with an aqueous vaccine of formalin-inactivated intact hepatitis B virus developed anti-HBs in low titers, but the development of antibody to the hepatitis B core antigen following challenge inoculations suggested that subclinical HBV infections may have occurred despite prior vaccination.
|Category: Journal Article|
|PubMed ID: #7130967||DOI: 10.1002/jmv.1890100109|
|Includes FDA Authors from Scientific Area(s): Biologics|
|Entry Created: 2012-12-09|