Scientific Publications by FDA Staff

J Pharm Biomed Anal 2012 Dec 5;75:153-7

Rapid-screening detection of acetildenafils, sildenafils and avanafil by ion mobility spectrometry.

Mans DJ, Callahan RJ, Dunn JD, Gryniewicz-Ruzicka CM

Ion mobility spectrometry was used as a rapid screening tool for the detection of acetildenafils, sildenafils and avanafil within adulterated herbal supplement matrices. Acetildenafils show a tendency for partial fragmentation during the desorption/ionization process affording two peaks in the ion mobility spectrum in addition to the intact compound. The fragmentation appears to occur alpha to the carbonyl group along the CN bond attaching the piperazine moiety, producing a common fragment (K(o)=1.0280cm(2)V(-1)s(-1)) along with the respective piperazine fragment. The sildenafils and avanafil afford one molecular ion peak per compound.