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Risk Anal 1996 Feb;16(1):107-13

On the correlation coefficient between the TD50 and the MTD.

Razzaghi M, Gaylor DW


The existence of correlation between the carcinogenic potency and the maximum tolerated dose has been the subject of many investigations in recent years. Several attempts have been made to quantify this correlation in different bioassay experiments. By using some distributional assumptions, Krewski et al. derive an analytic expression for the coefficient of correlation between the carcinogenic potency TD50 and the maximum tolerated dose. Here, we discuss the deviation that may result in using their analytical expression. By taking a more general approach we derive an expression for the correlation coefficient which includes the result of Krewski et al. as a special case, and show that their expression may overestimate the correlation in some instances and yet underestimate the correlation in other instances. The proposed method is illustrated by application to a real dataset.

Category: Journal Article
PubMed ID: #8868225 DOI: 10.1111/j.1539-6924.1996.tb01440.x
Includes FDA Authors from Scientific Area(s): Toxicological Research
Entry Created: 2012-12-25