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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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J Agric Food Chem 2013 Jul 31;61(30):7250-7

Rapid Determination of Silver in Nanobased Liquid Dietary Supplements Using a Portable X-ray Fluorescence Analyzer.

Sanchez-Pomales G, Mudalige TK, Lim JH, Linder SW


This paper reports a rapid and straightforward method for the quantitation of total Ag content in nanobased commercially available liquid dietary supplements using a portable X-ray fluorescence (pXRF) analyzer. Figures of merits were evaluated by analyzing a series of AgNO3 standards. This method was shown to have a detection limit of 3 ppm, a quantitation limit of 10 ppm, and a broad linear range from the detection limit to 10000 ppm (1%). Accurate detection and quantitation of Ag content in well-characterized Ag nanoparticle samples and in nanobased liquid dietary supplements were achieved with good correlation (i.e., percentage difference average values under 15%) between the total Ag concentration obtained by the pXRF analyzer and by inductively coupled plasma mass spectrometry (ICP-MS). Furthermore, accurate quantitation of Ag in the presence of high concentrations of potential spectral interferences was also demonstrated.

Category: Journal Article
PubMed ID: #23805852 DOI: 10.1021/jf402018t
Includes FDA Authors from Scientific Area(s): Regulatory Affairs
Entry Created: 2013-07-30 Entry Last Modified: 2014-01-11