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U.S. Department of Health and Human Services

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Genome Announc 2013 Aug 22;1(4)

Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a.

Xu D, Cisar JO, Poly F, Yang J, Albanese J, Dharmasena M, Wai T, Guerry P, Kopecko DJ


Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity.

Category: Journal Article
PubMed ID: #23969054 DOI: 10.1128/genomeA.00650-13
PubMed Central ID: #PMC3751609
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2013-08-24 Entry Last Modified: 2014-06-07