Scientific Publications by FDA Staff

Genome Announc 2013 Aug 22;1(4)

Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a.

Xu D, Cisar JO, Poly F, Yang J, Albanese J, Dharmasena M, Wai T, Guerry P, Kopecko DJ

Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity.