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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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J Biopharm Stat 2013;23(4):848-55

Estimation of the common risk difference in stratified paired binary data with homogeneous stratum effect.

Zhao YD, Rahardja D


McNemar's test is commonly used to test for the risk difference between two binary variables on matched pairs. For stratified paired binary data, recently a test for the homogeneous stratum effect (HSE) has been developed. If HSE is rejected, then McNemar's test should be applied by stratum; otherwise, in this article we propose a concept of common risk difference (CRD) across the strata and derive point estimators and confidence intervals for CRD. We use a cancer study for illustration and conduct simulations to recommend point estimators and associated confidence intervals with good statistical properties.

Category: Journal Article
PubMed ID: #23786205 DOI: 10.1080/10543406.2013.789888
Includes FDA Authors from Scientific Area(s): Medical Devices
Entry Created: 2013-09-20