Scientific Publications by FDA Staff
J Biopharm Stat 2013;23(4):848-55
Estimation of the common risk difference in stratified paired binary data with homogeneous stratum effect.
Zhao YD, Rahardja D
McNemar's test is commonly used to test for the risk difference between two binary variables on matched pairs. For stratified paired binary data, recently a test for the homogeneous stratum effect (HSE) has been developed. If HSE is rejected, then McNemar's test should be applied by stratum; otherwise, in this article we propose a concept of common risk difference (CRD) across the strata and derive point estimators and confidence intervals for CRD. We use a cancer study for illustration and conduct simulations to recommend point estimators and associated confidence intervals with good statistical properties.
|Category: Journal Article|
|PubMed ID: #23786205||DOI: 10.1080/10543406.2013.789888|
|Includes FDA Authors from Scientific Area(s): Medical Devices|
|Entry Created: 2013-09-20|