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U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

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J Pharm Biomed Anal 2013 Aug 31;88C:136-43

Screening for multiple weight loss and related drugs in dietary supplement materials by flow injection tandem mass spectrometry and their confirmation by liquid chromatography tandem mass spectrometry.

Song F, Monroe D, El-Demerdash A, Palmer C


A new method has been developed using flow injection tandem mass spectrometry to semi-quantitatively screen for weight loss drugs, including sibutramine, N-desmethylsibutramine, N-didesmethylsibutramine, and phenolphthalein in dietary supplements. Positive identification of these drugs in samples was further confirmed and quantified by liquid chromatography tandem mass spectrometry. The degradation products of sibutramine were observed and identified by LC-MS/MS which include N-desmethylsibutramine, N-didesmethylsibutramine, N-formyldesmethylsibutramine, and N-formyldidesmethylsibutramine.

Category: Journal Article
PubMed ID: #24055849 DOI: 10.1016/j.jpba.2013.08.031
Includes FDA Authors from Scientific Area(s): Regulatory Affairs
Entry Created: 2013-09-24 Entry Last Modified: 2014-02-09