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U.S. Department of Health and Human Services

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Virology 2013 Dec;447(1-2):208-12

Coding potential of UL/b' from the initial source of rhesus cytomegalovirus Strain 68-1.

Gill RB, Jason Bowman J, Krogmann T, Wollenberg K, Asher DM, Cohen JI


Rhesus cytomegalovirus (RhCMV) 68-1 is the prototypic strain of RhCMV that has been used for pathogenesis and vaccine development. We determined the complete sequence of the RhCMV 68-1 UL/b' region directly from the original urine from which RhCMV 68-1 was isolated in 1968, and compared it to other RhCMVs. The laboratory passaged RhCMV 68-1 has inversions, deletions, and stop codons in UL/b' that are absent in the original isolate and other low passage RhCMV isolates. Fourteen of the 17 open reading frames (ORFs) in 68-1 UL/b' in the original isolate share >95% amino acid identity with low passage RhCMV. The original isolate retains 6 ORFs that encode alpha-chemokine-like proteins, including RhUL146 and RhUL146b that share only 92% and 81% amino acid identity, respectively, with a contemporary low passage RhCMV isolate. Identification of the original RhCMV 68-1 UL/b' sequence is important for using RhCMV 68-1 in pathogenesis and vaccine studies.

Category: Journal Article
PubMed ID: #24210116 DOI: 10.1016/j.virol.2013.08.026
Includes FDA Authors from Scientific Area(s): Biologics
Entry Created: 2013-12-06