• Decrease font size
  • Return font size to normal
  • Increase font size
U.S. Department of Health and Human Services

Scientific Publications by FDA Staff

  • Print
  • Share
  • E-mail

Search Publications



Starting Date

Ending Date

Order by

Entry Details

Dis Markers 2013;35(6):661-7

Sex-specific genomic biomarkers for individualized treatment of life-threatening diseases.

Moon H, Lopez KL, Lin GI, Chen JJ


Numerous studies have demonstrated sex differences in drug reactions to the same drug treatment, steering away from the traditional view of one-size-fits-all medicine. A premise of this study is that the sex of a patient influences difference in disease characteristics and risk factors. In this study, we intend to exploit and to obtain better sex-specific biomarkers from gene-expression data. We propose a procedure to isolate a set of important genes as sex-specific genomic biomarkers, which may enable more effective patient treatment. A set of sex-specific genes is obtained by a variable importance ranking using a combination of cross-validation methods. The proposed procedure is applied to three gene-expression datasets.

Category: Journal Article
PubMed ID: #24302811 DOI: 10.1155/2013/393020
PubMed Central ID: #PMC3834650
Includes FDA Authors from Scientific Area(s): Toxicological Research
Entry Created: 2014-02-02