Scientific Publications by FDA Staff
Dis Markers 2013;35(6):661-7
Sex-specific genomic biomarkers for individualized treatment of life-threatening diseases.
Moon H, Lopez KL, Lin GI, Chen JJ
Numerous studies have demonstrated sex differences in drug reactions to the same drug treatment, steering away from the traditional view of one-size-fits-all medicine. A premise of this study is that the sex of a patient influences difference in disease characteristics and risk factors. In this study, we intend to exploit and to obtain better sex-specific biomarkers from gene-expression data. We propose a procedure to isolate a set of important genes as sex-specific genomic biomarkers, which may enable more effective patient treatment. A set of sex-specific genes is obtained by a variable importance ranking using a combination of cross-validation methods. The proposed procedure is applied to three gene-expression datasets.
|Category: Journal Article|
|PubMed ID: #24302811||DOI: 10.1155/2013/393020|
|PubMed Central ID: #PMC3834650|
|Includes FDA Authors from Scientific Area(s): Toxicological Research|
|Entry Created: 2014-02-02|