Scientific Publications by FDA Staff

Int J Cardiol 2014 Mar 1;172(1):196-201

Infiltrated atrial fat characterizes underlying atrial fibrillation substrate in patients at risk as defined by the ARIC atrial fibrillation risk score.

Tereshchenko LG, Rizzi P, Mewton N, Volpe GJ, Murthy S, Strauss DG, Liu CY, Marchlinski FE, Spooner P, Berger RD, Kellman P, Lima JA

BACKGROUND: It is known that expanded epicardial fat is associated with atrial fibrillation (AF). However, infiltrated intraatrial fat has not been previously quantified in individuals at risk as determined by the ARIC AF risk score. METHODS: Patients in sinus rhythm (N=90, age 57+/-10years; 55 men [63.2%]), in 3 groups at risk of AF as determined by the ARIC AF risk score [low (/=19 points; n=23) risk of AF], and paroxysmal AF (n=12) underwent cardiac magnetic resonance study. Intraatrial and epicardial fat was analyzed with a Dark-blood DIR-prepared Fat-Water-separated sequence in the horizontal longitudinal axis. OsiriX DICOM viewer (Geneva, Switzerland) was used to quantify the intraatrial fat area. Width of the cephalad portion of the interatrial septum was measured at the level of the fossa ovalis. RESULTS: Intraatrial fat monotonically increased with growing AF risk in study groups (low AF risk 16+/-4 vs. moderate AF risk 32+/-18 vs. high AF risk 81+/-83mm2; ANOVA P=0.012). Log-transformed intraatrial fat predicted ARIC AF risk score in multivariate ordered probit regression after adjustment for sex, race, left and right atrial area indices, and body mass index (beta-coefficient 0.50 [95% CI 0.03-0.97]; P=0.037), whereas epicardial fat did not. Interatrial septum width showed similar association (3.0+/-1.4 vs. 5.0+/-1.8 vs. 7.1+/-2.7mm; ANOVA P<0.001; adjusted beta-coefficient 2.80 [95% CI 1.19-4.41]; P=0.001). CONCLUSIONS: Infiltrated intraatrial fat characterizes evolving substrate in individuals at risk of AF.