Scientific Publications by FDA Staff

MMWR Morb Mortal Wkly Rep 2014 Apr 4;63(13):294-5

Notes from the field: multistate outbreak of listeriosis linked to soft-ripened cheese--United States, 2013.

Choi MJ, Jackson KA, Medu C, Beal J, Rigdon CE, Cloyd TC, Forstner MJ, Ball J, Bosch S, Bottichio L, Cantu V, Melka DC, Ishow W, Slette S, Melka DC, Irvin K, Melka DC, Wise M, Tarr C, Mahon B, Smith KE, Silk BJ

On June 27, 2013, the Minnesota Department of Health notified CDC of two patients with invasive Listeria monocytogenes infections (listeriosis) whose clinical isolates had indistinguishable pulsed-field gel electrophoresis (PFGE) patterns. A query of PulseNet, the national molecular subtyping network for foodborne disease surveillance, identified clinical and environmental isolates from other states. On June 28, CDC learned from the Food and Drug Administration's Coordinated Outbreak Response and Evaluation Network that environmental isolates indistinguishable from those of the two patients had been collected from Crave Brothers Farmstead Cheese during 2010-2011. An outbreak-related case was defined as isolation of L. monocytogenes with the outbreak PFGE pattern from an anatomic site that is normally sterile (e.g., blood or cerebrospinal fluid), or from a product of conception, with an isolate upload date during May 20-June 28, 2013. As of June 28, five cases were identified in four states (Minnesota, two cases; Illinois, Indiana, and Ohio, one each). Median age of the five patients was 58 years (range: 31-67 years). Four patients were female, including one who was pregnant at the time of infection. All five were hospitalized. One death and one miscarriage were reported.