Scientific Publications by FDA Staff
Biomed Opt Express 2014 Jul 28;5(8):2823-36
Longitudinal vascular dynamics following cranial window and electrode implantation measured with speckle variance optical coherence angiography.
Hammer DX, Lozzi A, Abliz E, Greenbaum N, Agrawal A, Krauthamer V, Welle CG
Speckle variance optical coherence angiography (OCA) was used to characterize the vascular tissue response from craniotomy, window implantation, and electrode insertion in mouse motor cortex. We observed initial vasodilation ~40% greater than original diameter 2-3 days post-surgery (dps). After 4 weeks, dilation subsided in large vessels (>50 microm diameter) but persisted in smaller vessels (25-50 microm diameter). Neovascularization began 8-12 dps and vessel migration continued throughout the study. Vasodilation and neovascularization were primarily associated with craniotomy and window implantation rather than electrode insertion. Initial evidence of capillary re-mapping in the region surrounding the implanted electrode was manifest in OCA image dissimilarity. Further investigation, including higher resolution imaging, is required to validate the finding. Spontaneous lesions also occurred in many electrode animals, though the inception point appeared random and not directly associated with electrode insertion. OCA allows high resolution, label-free in vivo visualization of neurovascular tissue, which may help determine any biological contribution to chronic electrode signal degradation. Vascular and flow-based biomarkers can aid development of novel neural prostheses.
|Category: Journal Article|
|PubMed ID: #25136505||DOI: 10.1364/BOE.5.002823|
|PubMed Central ID: #PMC4133009|
|Includes FDA Authors from Scientific Area(s): Medical Devices|
|Entry Created: 2014-08-20|