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Clin Pharmacol Ther 2014 Nov;96(5):536-7

Application of systems pharmacology to explore mechanisms of hepatotoxicity.

Shon J, Abernethy DR

Abstract

Advances in systems biology have allowed the development of a highly characterized systems pharmacology model to study mechanisms of drug-induced hepatotoxicity. In this issue of CPT, Yang et al. describe a model, DILIsym, used to characterize mechanisms of hepatotoxicity of troglitazone. Their modeling approach has provided new insight into troglitazone-induced hepatotoxicity in humans but is not associated with hepatotoxicity in rats, consistent with preclinical data for this drug.

Category: Journal Article, Editorial
PubMed ID: #25336266 DOI: 10.1038/clpt.2014.167
Includes FDA Authors from Scientific Area(s): Drugs
Entry Created: 2014-10-23 Entry Last Modified: 2014-11-22
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