Scientific Publications by FDA Staff

Angew Chem Int Ed Engl 2015 Feb 2;54(6):1832-5

Acquired superoxide-scavenging ability of ceria nanoparticles.

Li Y, He X, Yin JJ, Ma Y, Zhang P, Li J, Ding Y, Zhang J, Zhao Y, Chai Z, Zhang Z

Ceria nanoparticles (nanoceria) are well known as a superoxide scavenger. However, inherent superoxide-scavenging ability has only been found in the nanoceria with sizes of less than 5 nm and with very limited shape diversity. Reported herein is a strategy to significantly improve the superoxide-scavenging activity of nanoceria sized at greater than 5 nm. The nanoceria with sizes of greater than 5 nm, with different shapes, and with a negligible Ce(3+) /Ce(4+) ratio can acquire remarkable superoxide-scavenging abilities through electron transfer. This method will make it possible to develop nanoceria-based superoxide-scavengers with long-acting activity and tailorable characteristics.